Single Case Research Design

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This chapter addresses the peculiarities, characteristics, and major fallacies of single case research designs. A single case study research design is a collective term for an in-depth analysis of a small non-random sample. The focus on this design is on in-depth. This characteristic distinguishes the case study research from other research designs that understand the individual case as a rather insignificant and interchangeable aspect of a population or sample. Also, researchers find relevant information on how to write a single case research design paper and learn about typical methodologies used for this research design. The chapter closes with referring to overlapping and adjacent research designs.

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Baškarada, S. (2014). Qualitative case studies guidelines. The Qualitative Report, 19 (40), 1–25.

Google Scholar  

Berg, B., & Lune, H. (2012). Qualitative research methods for the social sciences. Pearson.

Bryman, A. (2004). Social research methods (2nd ed.). Oxford University Press, 592.

Burns, R. B. (2000). Introduction to research methods. United States of America.

Creswell, J. W. (2013). Qualitative inquiry and research design. Choosing among five approaches (3rd ed.). SAGE.

Darke, P., Shanks, G., & Broadbent, M. (1998). Successfully completing case study research: Combining rigour, relevance and pragmatism. Inform Syst J, 8 (4), 273–289.

Article   Google Scholar  

Dey, I. (1999). Grounding grounded theory: Guidelines for qualitative inquiry . Academic Press.

Dick, B. (2005). Grounded theory: A thumbnail sketch. Retrieved 11 June 2021 from http://www.scu.edu.au/schools/gcm/ar/arp/grounded.html .

Dooley, L. M. (2002). Case study research and theory building. Advances in Developing Human Resources, 4 (3), 335–354.

Edmonds, W. A., & Kennedy, T. D. (2012). An applied reference guide to research designs: Quantitative, qualitative, and mixed methods . Thousand Oaks, CA: Sage.

Edmondson, A. & McManus, S. (2007). Methodological fit in management field research. The Academy of Management Review, 32 (4), 1155–1179.

Eisenhardt, K. M. (1989). Building theories from case study research. Academy of Management Review, 14 (4), 532–550.

Glaser, B., & Strauss, A. (1967). The discovery of grounded theory: Strategies for qualitative research . Sociology Press.

Flynn, B. B., Sakakibara, S., Schroeder, R. G., Bates, K. A., & Flynn, E. J. (1990). Empirical research methods in operations management. Journal of Operations Management, 9 (2), 250–284.

Flyvbjerg, B. (2006). Five misunderstandings about case-study research. Qualitative Inquiry, 12 (2), 219–245.

General Accounting Office (1990). Case study evaluations. Retrieved May 15, 2021, from https://www.gao.gov/assets/pemd-10.1.9.pdf .

Gomm, R. (2000). Case study method. Key issues, key texts . SAGE.

Halaweh, M. (2012). Integration of grounded theory and case study: An exemplary application from e-commerce security perception research. Journal of Information Technology Theory and Application (JITTA), 13 (1).

Hancock, D., & Algozzine, B. (2016). Doing case study research: A practical guide for beginning researchers (3rd ed.). Teachers College Press.

Hekkala, R. (2007). Grounded theory—the two faces of the methodology and their manifestation in IS research. In Proceedings of the 30th Information Systems Research Seminar in Scandinavia IRIS, 11–14 August, Tampere, Finland (pp. 1–12).

Hyett, N., Kenny, A., & Dickson-Swift, V. (2014). Methodology or method? A critical review of qualitative case study reports. International Journal of Qualitative Studies on Health and Well-Being, 9 , 23606.

Keating, P. J. (1995). A framework for classifying and evaluating the theoretical contributions of case research in management accounting. Journal of Management Accounting Research, 7 , 66.

Levy, J. S. (2008). Case studies: Types, designs, and logics of inference. Conflict Management and Peace Science, 25 (1), 1–18.

Meyer, J.-A., & Kittel-Wegner, E. (2002). Die Fallstudie in der betriebswirtschaftlichen Forschung und Lehre . Stiftungslehrstuhl für ABWL, insb. kleine und mittlere Unternehmen, Universität.

Mitchell, J. C. (1983). Case and situation analysis. The Sociological Review, 31 (2), 187–211.

Ng, Y. N. K. & Hase, S. (2008). Grounded suggestions for doing a grounded theory business research. Electronic Journal on Business Research Methods, 6 (2).

Ng. (2005). A principal-distributor collaboration moden in the crane industry. Ph.D. Thesis, Graduate College of Management, Southern Cross University, Australia.

Ridder, H.-G. (2016). Case study research. Approaches, methods, contribution to theory. Sozialwissenschaftliche Forschungsmethoden (vol. 12). Rainer Hampp Verlag.

Ridder, H.-G. (2017). The theory contribution of case study research designs. Business Research, 10 (2), 281–305.

Maoz, Z. (2002). Case study methodology in international studies: from storytelling to hypothesis testing. In F. P. Harvey & M. Brecher (Eds.). Evaluating methodology in international studies . University of Michigan Press.

May, T. (2011). Social research: Issues, methods and process . Open University Press/Mc.

Merriam, S. B. (2009). Qualitative research in practice: Examples for discussion and analysis .

Onwuegbuzie, A. J., Leech, N. L., & Collins, K. M. (2012). Qualitative analysis techniques for the review of the literature. Qualitative Report, 17 (56).

Piekkari, R., Welch, C., & Paavilainen, E. (2009). The case study as disciplinary convention. Organizational Research Methods, 12 (3), 567–589.

Stake, R. E. (1995). The art of case study research . Sage.

Stake, R. E. (2005). Qualitative case studies. The SAGE handbook of qualitative research (3rd ed.), ed. N. K. Denzin & Y. S. Lincoln (pp. 443–466).

Strauss, A. L., & Corbin, J. (1990). Basics of qualitative research: Grounded theory procedures and techniques . Sage publications.

Strauss, A. L., & Corbin, J. (1998). Basics of qualitative research techniques and procedures for developing grounded theory . Sage.

Tight, M. (2003). Researching higher education . Society for Research into Higher Education; Open University Press.

Tight, M. (2010). The curious case of case study: A viewpoint. International Journal of Social Research Methodology, 13 (4), 329–339.

Walsham, G. (2006). Doing interpretive research. European Journal of Information Systems, 15 (3), 320–330.

Welch, C., Piekkari, R., Plakoyiannaki, E., & Paavilainen-Mäntymäki, E. (2011). Theorising from case studies: Towards a pluralist future for international business research. Journal of International Business Studies, 42 (5), 740–762.

Woods, M. (2009). A contingency theory perspective on the risk management control system within Birmingham City Council. Management Accounting Research, 20 (1), 69–81.

Yin, R. K. (1994). Discovering the future of the case study. Method in evaluation research. American Journal of Evaluation, 15 (3), 283–290.

Yin, R. K. (2014). Case study research. Design and methods (5th ed.). SAGE.

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Hunziker, S., Blankenagel, M. (2021). Single Case Research Design. In: Research Design in Business and Management. Springer Gabler, Wiesbaden. https://doi.org/10.1007/978-3-658-34357-6_8

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Home » Case Study – Methods, Examples and Guide

Case Study – Methods, Examples and Guide

Table of Contents

Case Study Research

A case study is a research method that involves an in-depth examination and analysis of a particular phenomenon or case, such as an individual, organization, community, event, or situation.

It is a qualitative research approach that aims to provide a detailed and comprehensive understanding of the case being studied. Case studies typically involve multiple sources of data, including interviews, observations, documents, and artifacts, which are analyzed using various techniques, such as content analysis, thematic analysis, and grounded theory. The findings of a case study are often used to develop theories, inform policy or practice, or generate new research questions.

Types of Case Study

Types and Methods of Case Study are as follows:

Single-Case Study

A single-case study is an in-depth analysis of a single case. This type of case study is useful when the researcher wants to understand a specific phenomenon in detail.

For Example , A researcher might conduct a single-case study on a particular individual to understand their experiences with a particular health condition or a specific organization to explore their management practices. The researcher collects data from multiple sources, such as interviews, observations, and documents, and uses various techniques to analyze the data, such as content analysis or thematic analysis. The findings of a single-case study are often used to generate new research questions, develop theories, or inform policy or practice.

Multiple-Case Study

A multiple-case study involves the analysis of several cases that are similar in nature. This type of case study is useful when the researcher wants to identify similarities and differences between the cases.

For Example, a researcher might conduct a multiple-case study on several companies to explore the factors that contribute to their success or failure. The researcher collects data from each case, compares and contrasts the findings, and uses various techniques to analyze the data, such as comparative analysis or pattern-matching. The findings of a multiple-case study can be used to develop theories, inform policy or practice, or generate new research questions.

Exploratory Case Study

An exploratory case study is used to explore a new or understudied phenomenon. This type of case study is useful when the researcher wants to generate hypotheses or theories about the phenomenon.

For Example, a researcher might conduct an exploratory case study on a new technology to understand its potential impact on society. The researcher collects data from multiple sources, such as interviews, observations, and documents, and uses various techniques to analyze the data, such as grounded theory or content analysis. The findings of an exploratory case study can be used to generate new research questions, develop theories, or inform policy or practice.

Descriptive Case Study

A descriptive case study is used to describe a particular phenomenon in detail. This type of case study is useful when the researcher wants to provide a comprehensive account of the phenomenon.

For Example, a researcher might conduct a descriptive case study on a particular community to understand its social and economic characteristics. The researcher collects data from multiple sources, such as interviews, observations, and documents, and uses various techniques to analyze the data, such as content analysis or thematic analysis. The findings of a descriptive case study can be used to inform policy or practice or generate new research questions.

Instrumental Case Study

An instrumental case study is used to understand a particular phenomenon that is instrumental in achieving a particular goal. This type of case study is useful when the researcher wants to understand the role of the phenomenon in achieving the goal.

For Example, a researcher might conduct an instrumental case study on a particular policy to understand its impact on achieving a particular goal, such as reducing poverty. The researcher collects data from multiple sources, such as interviews, observations, and documents, and uses various techniques to analyze the data, such as content analysis or thematic analysis. The findings of an instrumental case study can be used to inform policy or practice or generate new research questions.

Case Study Data Collection Methods

Here are some common data collection methods for case studies:

Interviews involve asking questions to individuals who have knowledge or experience relevant to the case study. Interviews can be structured (where the same questions are asked to all participants) or unstructured (where the interviewer follows up on the responses with further questions). Interviews can be conducted in person, over the phone, or through video conferencing.

Observations

Observations involve watching and recording the behavior and activities of individuals or groups relevant to the case study. Observations can be participant (where the researcher actively participates in the activities) or non-participant (where the researcher observes from a distance). Observations can be recorded using notes, audio or video recordings, or photographs.

Documents can be used as a source of information for case studies. Documents can include reports, memos, emails, letters, and other written materials related to the case study. Documents can be collected from the case study participants or from public sources.

Surveys involve asking a set of questions to a sample of individuals relevant to the case study. Surveys can be administered in person, over the phone, through mail or email, or online. Surveys can be used to gather information on attitudes, opinions, or behaviors related to the case study.

Artifacts are physical objects relevant to the case study. Artifacts can include tools, equipment, products, or other objects that provide insights into the case study phenomenon.

How to conduct Case Study Research

Conducting a case study research involves several steps that need to be followed to ensure the quality and rigor of the study. Here are the steps to conduct case study research:

  • Define the research questions: The first step in conducting a case study research is to define the research questions. The research questions should be specific, measurable, and relevant to the case study phenomenon under investigation.
  • Select the case: The next step is to select the case or cases to be studied. The case should be relevant to the research questions and should provide rich and diverse data that can be used to answer the research questions.
  • Collect data: Data can be collected using various methods, such as interviews, observations, documents, surveys, and artifacts. The data collection method should be selected based on the research questions and the nature of the case study phenomenon.
  • Analyze the data: The data collected from the case study should be analyzed using various techniques, such as content analysis, thematic analysis, or grounded theory. The analysis should be guided by the research questions and should aim to provide insights and conclusions relevant to the research questions.
  • Draw conclusions: The conclusions drawn from the case study should be based on the data analysis and should be relevant to the research questions. The conclusions should be supported by evidence and should be clearly stated.
  • Validate the findings: The findings of the case study should be validated by reviewing the data and the analysis with participants or other experts in the field. This helps to ensure the validity and reliability of the findings.
  • Write the report: The final step is to write the report of the case study research. The report should provide a clear description of the case study phenomenon, the research questions, the data collection methods, the data analysis, the findings, and the conclusions. The report should be written in a clear and concise manner and should follow the guidelines for academic writing.

Examples of Case Study

Here are some examples of case study research:

  • The Hawthorne Studies : Conducted between 1924 and 1932, the Hawthorne Studies were a series of case studies conducted by Elton Mayo and his colleagues to examine the impact of work environment on employee productivity. The studies were conducted at the Hawthorne Works plant of the Western Electric Company in Chicago and included interviews, observations, and experiments.
  • The Stanford Prison Experiment: Conducted in 1971, the Stanford Prison Experiment was a case study conducted by Philip Zimbardo to examine the psychological effects of power and authority. The study involved simulating a prison environment and assigning participants to the role of guards or prisoners. The study was controversial due to the ethical issues it raised.
  • The Challenger Disaster: The Challenger Disaster was a case study conducted to examine the causes of the Space Shuttle Challenger explosion in 1986. The study included interviews, observations, and analysis of data to identify the technical, organizational, and cultural factors that contributed to the disaster.
  • The Enron Scandal: The Enron Scandal was a case study conducted to examine the causes of the Enron Corporation’s bankruptcy in 2001. The study included interviews, analysis of financial data, and review of documents to identify the accounting practices, corporate culture, and ethical issues that led to the company’s downfall.
  • The Fukushima Nuclear Disaster : The Fukushima Nuclear Disaster was a case study conducted to examine the causes of the nuclear accident that occurred at the Fukushima Daiichi Nuclear Power Plant in Japan in 2011. The study included interviews, analysis of data, and review of documents to identify the technical, organizational, and cultural factors that contributed to the disaster.

Application of Case Study

Case studies have a wide range of applications across various fields and industries. Here are some examples:

Business and Management

Case studies are widely used in business and management to examine real-life situations and develop problem-solving skills. Case studies can help students and professionals to develop a deep understanding of business concepts, theories, and best practices.

Case studies are used in healthcare to examine patient care, treatment options, and outcomes. Case studies can help healthcare professionals to develop critical thinking skills, diagnose complex medical conditions, and develop effective treatment plans.

Case studies are used in education to examine teaching and learning practices. Case studies can help educators to develop effective teaching strategies, evaluate student progress, and identify areas for improvement.

Social Sciences

Case studies are widely used in social sciences to examine human behavior, social phenomena, and cultural practices. Case studies can help researchers to develop theories, test hypotheses, and gain insights into complex social issues.

Law and Ethics

Case studies are used in law and ethics to examine legal and ethical dilemmas. Case studies can help lawyers, policymakers, and ethical professionals to develop critical thinking skills, analyze complex cases, and make informed decisions.

Purpose of Case Study

The purpose of a case study is to provide a detailed analysis of a specific phenomenon, issue, or problem in its real-life context. A case study is a qualitative research method that involves the in-depth exploration and analysis of a particular case, which can be an individual, group, organization, event, or community.

The primary purpose of a case study is to generate a comprehensive and nuanced understanding of the case, including its history, context, and dynamics. Case studies can help researchers to identify and examine the underlying factors, processes, and mechanisms that contribute to the case and its outcomes. This can help to develop a more accurate and detailed understanding of the case, which can inform future research, practice, or policy.

Case studies can also serve other purposes, including:

  • Illustrating a theory or concept: Case studies can be used to illustrate and explain theoretical concepts and frameworks, providing concrete examples of how they can be applied in real-life situations.
  • Developing hypotheses: Case studies can help to generate hypotheses about the causal relationships between different factors and outcomes, which can be tested through further research.
  • Providing insight into complex issues: Case studies can provide insights into complex and multifaceted issues, which may be difficult to understand through other research methods.
  • Informing practice or policy: Case studies can be used to inform practice or policy by identifying best practices, lessons learned, or areas for improvement.

Advantages of Case Study Research

There are several advantages of case study research, including:

  • In-depth exploration: Case study research allows for a detailed exploration and analysis of a specific phenomenon, issue, or problem in its real-life context. This can provide a comprehensive understanding of the case and its dynamics, which may not be possible through other research methods.
  • Rich data: Case study research can generate rich and detailed data, including qualitative data such as interviews, observations, and documents. This can provide a nuanced understanding of the case and its complexity.
  • Holistic perspective: Case study research allows for a holistic perspective of the case, taking into account the various factors, processes, and mechanisms that contribute to the case and its outcomes. This can help to develop a more accurate and comprehensive understanding of the case.
  • Theory development: Case study research can help to develop and refine theories and concepts by providing empirical evidence and concrete examples of how they can be applied in real-life situations.
  • Practical application: Case study research can inform practice or policy by identifying best practices, lessons learned, or areas for improvement.
  • Contextualization: Case study research takes into account the specific context in which the case is situated, which can help to understand how the case is influenced by the social, cultural, and historical factors of its environment.

Limitations of Case Study Research

There are several limitations of case study research, including:

  • Limited generalizability : Case studies are typically focused on a single case or a small number of cases, which limits the generalizability of the findings. The unique characteristics of the case may not be applicable to other contexts or populations, which may limit the external validity of the research.
  • Biased sampling: Case studies may rely on purposive or convenience sampling, which can introduce bias into the sample selection process. This may limit the representativeness of the sample and the generalizability of the findings.
  • Subjectivity: Case studies rely on the interpretation of the researcher, which can introduce subjectivity into the analysis. The researcher’s own biases, assumptions, and perspectives may influence the findings, which may limit the objectivity of the research.
  • Limited control: Case studies are typically conducted in naturalistic settings, which limits the control that the researcher has over the environment and the variables being studied. This may limit the ability to establish causal relationships between variables.
  • Time-consuming: Case studies can be time-consuming to conduct, as they typically involve a detailed exploration and analysis of a specific case. This may limit the feasibility of conducting multiple case studies or conducting case studies in a timely manner.
  • Resource-intensive: Case studies may require significant resources, including time, funding, and expertise. This may limit the ability of researchers to conduct case studies in resource-constrained settings.

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  • What Is a Case Study? | Definition, Examples & Methods

What Is a Case Study? | Definition, Examples & Methods

Published on May 8, 2019 by Shona McCombes . Revised on November 20, 2023.

A case study is a detailed study of a specific subject, such as a person, group, place, event, organization, or phenomenon. Case studies are commonly used in social, educational, clinical, and business research.

A case study research design usually involves qualitative methods , but quantitative methods are sometimes also used. Case studies are good for describing , comparing, evaluating and understanding different aspects of a research problem .

Table of contents

When to do a case study, step 1: select a case, step 2: build a theoretical framework, step 3: collect your data, step 4: describe and analyze the case, other interesting articles.

A case study is an appropriate research design when you want to gain concrete, contextual, in-depth knowledge about a specific real-world subject. It allows you to explore the key characteristics, meanings, and implications of the case.

Case studies are often a good choice in a thesis or dissertation . They keep your project focused and manageable when you don’t have the time or resources to do large-scale research.

You might use just one complex case study where you explore a single subject in depth, or conduct multiple case studies to compare and illuminate different aspects of your research problem.

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Once you have developed your problem statement and research questions , you should be ready to choose the specific case that you want to focus on. A good case study should have the potential to:

  • Provide new or unexpected insights into the subject
  • Challenge or complicate existing assumptions and theories
  • Propose practical courses of action to resolve a problem
  • Open up new directions for future research

TipIf your research is more practical in nature and aims to simultaneously investigate an issue as you solve it, consider conducting action research instead.

Unlike quantitative or experimental research , a strong case study does not require a random or representative sample. In fact, case studies often deliberately focus on unusual, neglected, or outlying cases which may shed new light on the research problem.

Example of an outlying case studyIn the 1960s the town of Roseto, Pennsylvania was discovered to have extremely low rates of heart disease compared to the US average. It became an important case study for understanding previously neglected causes of heart disease.

However, you can also choose a more common or representative case to exemplify a particular category, experience or phenomenon.

Example of a representative case studyIn the 1920s, two sociologists used Muncie, Indiana as a case study of a typical American city that supposedly exemplified the changing culture of the US at the time.

While case studies focus more on concrete details than general theories, they should usually have some connection with theory in the field. This way the case study is not just an isolated description, but is integrated into existing knowledge about the topic. It might aim to:

  • Exemplify a theory by showing how it explains the case under investigation
  • Expand on a theory by uncovering new concepts and ideas that need to be incorporated
  • Challenge a theory by exploring an outlier case that doesn’t fit with established assumptions

To ensure that your analysis of the case has a solid academic grounding, you should conduct a literature review of sources related to the topic and develop a theoretical framework . This means identifying key concepts and theories to guide your analysis and interpretation.

There are many different research methods you can use to collect data on your subject. Case studies tend to focus on qualitative data using methods such as interviews , observations , and analysis of primary and secondary sources (e.g., newspaper articles, photographs, official records). Sometimes a case study will also collect quantitative data.

Example of a mixed methods case studyFor a case study of a wind farm development in a rural area, you could collect quantitative data on employment rates and business revenue, collect qualitative data on local people’s perceptions and experiences, and analyze local and national media coverage of the development.

The aim is to gain as thorough an understanding as possible of the case and its context.

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In writing up the case study, you need to bring together all the relevant aspects to give as complete a picture as possible of the subject.

How you report your findings depends on the type of research you are doing. Some case studies are structured like a standard scientific paper or thesis , with separate sections or chapters for the methods , results and discussion .

Others are written in a more narrative style, aiming to explore the case from various angles and analyze its meanings and implications (for example, by using textual analysis or discourse analysis ).

In all cases, though, make sure to give contextual details about the case, connect it back to the literature and theory, and discuss how it fits into wider patterns or debates.

If you want to know more about statistics , methodology , or research bias , make sure to check out some of our other articles with explanations and examples.

  • Normal distribution
  • Degrees of freedom
  • Null hypothesis
  • Discourse analysis
  • Control groups
  • Mixed methods research
  • Non-probability sampling
  • Quantitative research
  • Ecological validity

Research bias

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  • Cognitive bias
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McCombes, S. (2023, November 20). What Is a Case Study? | Definition, Examples & Methods. Scribbr. Retrieved April 12, 2024, from https://www.scribbr.com/methodology/case-study/

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Single case studies are a powerful tool for developing, testing and extending theories

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Psychology embraces a diverse range of methodologies. However, most rely on averaging group data to draw conclusions. In this Perspective, we argue that single case methodology is a valuable tool for developing and extending psychological theories. We stress the importance of single case and case series research, drawing on classic and contemporary cases in which cognitive and perceptual deficits provide insights into typical cognitive processes in domains such as memory, delusions, reading and face perception. We unpack the key features of single case methodology, describe its strengths, its value in adjudicating between theories, and outline its benefits for a better understanding of deficits and hence more appropriate interventions. The unique insights that single case studies have provided illustrate the value of in-depth investigation within an individual. Single case methodology has an important place in the psychologist’s toolkit and it should be valued as a primary research tool.

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Schubert, T. M. et al. Lack of awareness despite complex visual processing: evidence from event-related potentials in a case of selective metamorphopsia. Proc. Natl Acad. Sci. USA 117 , 16055–16064 (2020).

Behrmann, M. & Plaut, D. C. Bilateral hemispheric processing of words and faces: evidence from word impairments in prosopagnosia and face impairments in pure alexia. Cereb. Cortex 24 , 1102–1118 (2014).

Plaut, D. C. & Behrmann, M. Complementary neural representations for faces and words: a computational exploration. Cogn. Neuropsychol. 28 , 251–275 (2011).

Haxby, J. V. et al. Distributed and overlapping representations of faces and objects in ventral temporal cortex. Science 293 , 2425–2430 (2001).

Hirshorn, E. A. et al. Decoding and disrupting left midfusiform gyrus activity during word reading. Proc. Natl Acad. Sci. USA 113 , 8162–8167 (2016).

Kosakowski, H. L. et al. Selective responses to faces, scenes, and bodies in the ventral visual pathway of infants. Curr. Biol. 32 , 265–274.e5 (2022).

Harlow, J. Passage of an iron rod through the head. Boston Med. Surgical J . https://doi.org/10.1176/jnp.11.2.281 (1848).

Broca, P. Remarks on the seat of the faculty of articulated language, following an observation of aphemia (loss of speech). Bull. Soc. Anat. 6 , 330–357 (1861).

Google Scholar  

Dejerine, J. Contribution A L’étude Anatomo-pathologique Et Clinique Des Différentes Variétés De Cécité Verbale: I. Cécité Verbale Avec Agraphie Ou Troubles Très Marqués De L’écriture; II. Cécité Verbale Pure Avec Intégrité De L’écriture Spontanée Et Sous Dictée (Société de Biologie, 1892).

Liepmann, H. Das Krankheitsbild der Apraxie (“motorischen Asymbolie”) auf Grund eines Falles von einseitiger Apraxie (Fortsetzung). Eur. Neurol. 8 , 102–116 (1900).

Article   Google Scholar  

Basso, A., Spinnler, H., Vallar, G. & Zanobio, M. E. Left hemisphere damage and selective impairment of auditory verbal short-term memory. A case study. Neuropsychologia 20 , 263–274 (1982).

Humphreys, G. W. & Riddoch, M. J. The fractionation of visual agnosia. In Visual Object Processing: A Cognitive Neuropsychological Approach 281–306 (Lawrence Erlbaum, 1987).

Whitworth, A., Webster, J. & Howard, D. A Cognitive Neuropsychological Approach To Assessment And Intervention In Aphasia (Psychology Press, 2014).

Caramazza, A. On drawing inferences about the structure of normal cognitive systems from the analysis of patterns of impaired performance: the case for single-patient studies. Brain Cogn. 5 , 41–66 (1986).

Caramazza, A. & McCloskey, M. The case for single-patient studies. Cogn. Neuropsychol. 5 , 517–527 (1988).

Shallice, T. Cognitive neuropsychology and its vicissitudes: the fate of Caramazza’s axioms. Cogn. Neuropsychol. 32 , 385–411 (2015).

Shallice, T. From Neuropsychology To Mental Structure (Cambridge Univ. Press, 1988).

Coltheart, M. Assumptions and methods in cognitive neuropscyhology. In The Handbook Of Cognitive Neuropsychology: What Deficits Reveal About The Human Mind (ed. Rapp, B.) 3–22 (Psychology Press, 2001).

McCloskey, M. & Chaisilprungraung, T. The value of cognitive neuropsychology: the case of vision research. Cogn. Neuropsychol. 34 , 412–419 (2017).

McCloskey, M. The future of cognitive neuropsychology. In The Handbook Of Cognitive Neuropsychology: What Deficits Reveal About The Human Mind (ed. Rapp, B.) 593–610 (Psychology Press, 2001).

Lashley, K. S. In search of the engram. In Physiological Mechanisms in Animal Behavior 454–482 (Academic Press, 1950).

Squire, L. R. & Wixted, J. T. The cognitive neuroscience of human memory since H.M. Annu. Rev. Neurosci. 34 , 259–288 (2011).

Stone, G. O., Vanhoy, M. & Orden, G. C. V. Perception is a two-way street: feedforward and feedback phonology in visual word recognition. J. Mem. Lang. 36 , 337–359 (1997).

Perfetti, C. A. The psycholinguistics of spelling and reading. In Learning To Spell: Research, Theory, And Practice Across Languages 21–38 (Lawrence Erlbaum, 1997).

Nickels, L. The autocue? self-generated phonemic cues in the treatment of a disorder of reading and naming. Cogn. Neuropsychol. 9 , 155–182 (1992).

Rapp, B., Benzing, L. & Caramazza, A. The autonomy of lexical orthography. Cogn. Neuropsychol. 14 , 71–104 (1997).

Bonin, P., Roux, S. & Barry, C. Translating nonverbal pictures into verbal word names. Understanding lexical access and retrieval. In Past, Present, And Future Contributions Of Cognitive Writing Research To Cognitive Psychology 315–522 (Psychology Press, 2011).

Bonin, P., Fayol, M. & Gombert, J.-E. Role of phonological and orthographic codes in picture naming and writing: an interference paradigm study. Cah. Psychol. Cogn./Current Psychol. Cogn. 16 , 299–324 (1997).

Bonin, P., Fayol, M. & Peereman, R. Masked form priming in writing words from pictures: evidence for direct retrieval of orthographic codes. Acta Psychol. 99 , 311–328 (1998).

Bentin, S., Allison, T., Puce, A., Perez, E. & McCarthy, G. Electrophysiological studies of face perception in humans. J. Cogn. Neurosci. 8 , 551–565 (1996).

Jeffreys, D. A. Evoked potential studies of face and object processing. Vis. Cogn. 3 , 1–38 (1996).

Laganaro, M., Morand, S., Michel, C. M., Spinelli, L. & Schnider, A. ERP correlates of word production before and after stroke in an aphasic patient. J. Cogn. Neurosci. 23 , 374–381 (2011).

Indefrey, P. & Levelt, W. J. M. The spatial and temporal signatures of word production components. Cognition 92 , 101–144 (2004).

Valente, A., Burki, A. & Laganaro, M. ERP correlates of word production predictors in picture naming: a trial by trial multiple regression analysis from stimulus onset to response. Front. Neurosci. 8 , 390 (2014).

Kittredge, A. K., Dell, G. S., Verkuilen, J. & Schwartz, M. F. Where is the effect of frequency in word production? Insights from aphasic picture-naming errors. Cogn. Neuropsychol. 25 , 463–492 (2008).

Domdei, N. et al. Ultra-high contrast retinal display system for single photoreceptor psychophysics. Biomed. Opt. Express 9 , 157 (2018).

Poldrack, R. A. et al. Long-term neural and physiological phenotyping of a single human. Nat. Commun. 6 , 8885 (2015).

Coltheart, M. The assumptions of cognitive neuropsychology: reflections on Caramazza (1984, 1986). Cogn. Neuropsychol. 34 , 397–402 (2017).

Badecker, W. & Caramazza, A. A final brief in the case against agrammatism: the role of theory in the selection of data. Cognition 24 , 277–282 (1986).

Fischer-Baum, S. Making sense of deviance: Identifying dissociating cases within the case series approach. Cogn. Neuropsychol. 30 , 597–617 (2013).

Nickels, L., Howard, D. & Best, W. On the use of different methodologies in cognitive neuropsychology: drink deep and from several sources. Cogn. Neuropsychol. 28 , 475–485 (2011).

Dell, G. S. & Schwartz, M. F. Who’s in and who’s out? Inclusion criteria, model evaluation, and the treatment of exceptions in case series. Cogn. Neuropsychol. 28 , 515–520 (2011).

Schwartz, M. F. & Dell, G. S. Case series investigations in cognitive neuropsychology. Cogn. Neuropsychol. 27 , 477–494 (2010).

Cohen, J. A power primer. Psychol. Bull. 112 , 155–159 (1992).

Martin, R. C. & Allen, C. Case studies in neuropsychology. In APA Handbook Of Research Methods In Psychology Vol. 2 Research Designs: Quantitative, Qualitative, Neuropsychological, And Biological (eds Cooper, H. et al.) 633–646 (American Psychological Association, 2012).

Leivada, E., Westergaard, M., Duñabeitia, J. A. & Rothman, J. On the phantom-like appearance of bilingualism effects on neurocognition: (how) should we proceed? Bilingualism 24 , 197–210 (2021).

Arnett, J. J. The neglected 95%: why American psychology needs to become less American. Am. Psychol. 63 , 602–614 (2008).

Stolz, J. A., Besner, D. & Carr, T. H. Implications of measures of reliability for theories of priming: activity in semantic memory is inherently noisy and uncoordinated. Vis. Cogn. 12 , 284–336 (2005).

Cipora, K. et al. A minority pulls the sample mean: on the individual prevalence of robust group-level cognitive phenomena — the instance of the SNARC effect. Preprint at psyArXiv https://doi.org/10.31234/osf.io/bwyr3 (2019).

Andrews, S., Lo, S. & Xia, V. Individual differences in automatic semantic priming. J. Exp. Psychol. Hum. Percept. Perform. 43 , 1025–1039 (2017).

Tan, L. C. & Yap, M. J. Are individual differences in masked repetition and semantic priming reliable? Vis. Cogn. 24 , 182–200 (2016).

Olsson-Collentine, A., Wicherts, J. M. & van Assen, M. A. L. M. Heterogeneity in direct replications in psychology and its association with effect size. Psychol. Bull. 146 , 922–940 (2020).

Gratton, C. & Braga, R. M. Editorial overview: deep imaging of the individual brain: past, practice, and promise. Curr. Opin. Behav. Sci. 40 , iii–vi (2021).

Fedorenko, E. The early origins and the growing popularity of the individual-subject analytic approach in human neuroscience. Curr. Opin. Behav. Sci. 40 , 105–112 (2021).

Xue, A. et al. The detailed organization of the human cerebellum estimated by intrinsic functional connectivity within the individual. J. Neurophysiol. 125 , 358–384 (2021).

Petit, S. et al. Toward an individualized neural assessment of receptive language in children. J. Speech Lang. Hear. Res. 63 , 2361–2385 (2020).

Jung, K.-H. et al. Heterogeneity of cerebral white matter lesions and clinical correlates in older adults. Stroke 52 , 620–630 (2021).

Falcon, M. I., Jirsa, V. & Solodkin, A. A new neuroinformatics approach to personalized medicine in neurology: the virtual brain. Curr. Opin. Neurol. 29 , 429–436 (2016).

Duncan, G. J., Engel, M., Claessens, A. & Dowsett, C. J. Replication and robustness in developmental research. Dev. Psychol. 50 , 2417–2425 (2014).

Open Science Collaboration. Estimating the reproducibility of psychological science. Science 349 , aac4716 (2015).

Tackett, J. L., Brandes, C. M., King, K. M. & Markon, K. E. Psychology’s replication crisis and clinical psychological science. Annu. Rev. Clin. Psychol. 15 , 579–604 (2019).

Munafò, M. R. et al. A manifesto for reproducible science. Nat. Hum. Behav. 1 , 0021 (2017).

Oldfield, R. C. & Wingfield, A. The time it takes to name an object. Nature 202 , 1031–1032 (1964).

Oldfield, R. C. & Wingfield, A. Response latencies in naming objects. Q. J. Exp. Psychol. 17 , 273–281 (1965).

Brysbaert, M. How many participants do we have to include in properly powered experiments? A tutorial of power analysis with reference tables. J. Cogn. 2 , 16 (2019).

Brysbaert, M. Power considerations in bilingualism research: time to step up our game. Bilingualism https://doi.org/10.1017/S1366728920000437 (2020).

Machery, E. What is a replication? Phil. Sci. 87 , 545–567 (2020).

Nosek, B. A. & Errington, T. M. What is replication? PLoS Biol. 18 , e3000691 (2020).

Li, X., Huang, L., Yao, P. & Hyönä, J. Universal and specific reading mechanisms across different writing systems. Nat. Rev. Psychol. 1 , 133–144 (2022).

Rapp, B. (Ed.) The Handbook Of Cognitive Neuropsychology: What Deficits Reveal About The Human Mind (Psychology Press, 2001).

Code, C. et al. Classic Cases In Neuropsychology (Psychology Press, 1996).

Patterson, K., Marshall, J. C. & Coltheart, M. Surface Dyslexia: Neuropsychological And Cognitive Studies Of Phonological Reading (Routledge, 2017).

Marshall, J. C. & Newcombe, F. Patterns of paralexia: a psycholinguistic approach. J. Psycholinguist. Res. 2 , 175–199 (1973).

Castles, A. & Coltheart, M. Varieties of developmental dyslexia. Cognition 47 , 149–180 (1993).

Khentov-Kraus, L. & Friedmann, N. Vowel letter dyslexia. Cogn. Neuropsychol. 35 , 223–270 (2018).

Winskel, H. Orthographic and phonological parafoveal processing of consonants, vowels, and tones when reading Thai. Appl. Psycholinguist. 32 , 739–759 (2011).

Hepner, C., McCloskey, M. & Rapp, B. Do reading and spelling share orthographic representations? Evidence from developmental dysgraphia. Cogn. Neuropsychol. 34 , 119–143 (2017).

Hanley, J. R. & Sotiropoulos, A. Developmental surface dysgraphia without surface dyslexia. Cogn. Neuropsychol. 35 , 333–341 (2018).

Zihl, J. & Heywood, C. A. The contribution of single case studies to the neuroscience of vision: single case studies in vision neuroscience. Psych. J. 5 , 5–17 (2016).

Bouvier, S. E. & Engel, S. A. Behavioral deficits and cortical damage loci in cerebral achromatopsia. Cereb. Cortex 16 , 183–191 (2006).

Zihl, J. & Heywood, C. A. The contribution of LM to the neuroscience of movement vision. Front. Integr. Neurosci. 9 , 6 (2015).

Dotan, D. & Friedmann, N. Separate mechanisms for number reading and word reading: evidence from selective impairments. Cortex 114 , 176–192 (2019).

McCloskey, M. & Schubert, T. Shared versus separate processes for letter and digit identification. Cogn. Neuropsychol. 31 , 437–460 (2014).

Fayol, M. & Seron, X. On numerical representations. Insights from experimental, neuropsychological, and developmental research. In Handbook of Mathematical Cognition (ed. Campbell, J.) 3–23 (Psychological Press, 2005).

Bornstein, B. & Kidron, D. P. Prosopagnosia. J. Neurol. Neurosurg. Psychiat. 22 , 124–131 (1959).

Kühn, C. D., Gerlach, C., Andersen, K. B., Poulsen, M. & Starrfelt, R. Face recognition in developmental dyslexia: evidence for dissociation between faces and words. Cogn. Neuropsychol. 38 , 107–115 (2021).

Barton, J. J. S., Albonico, A., Susilo, T., Duchaine, B. & Corrow, S. L. Object recognition in acquired and developmental prosopagnosia. Cogn. Neuropsychol. 36 , 54–84 (2019).

Renault, B., Signoret, J.-L., Debruille, B., Breton, F. & Bolgert, F. Brain potentials reveal covert facial recognition in prosopagnosia. Neuropsychologia 27 , 905–912 (1989).

Bauer, R. M. Autonomic recognition of names and faces in prosopagnosia: a neuropsychological application of the guilty knowledge test. Neuropsychologia 22 , 457–469 (1984).

Haan, E. H. F., de, Young, A. & Newcombe, F. Face recognition without awareness. Cogn. Neuropsychol. 4 , 385–415 (1987).

Ellis, H. D. & Lewis, M. B. Capgras delusion: a window on face recognition. Trends Cogn. Sci. 5 , 149–156 (2001).

Ellis, H. D., Young, A. W., Quayle, A. H. & De Pauw, K. W. Reduced autonomic responses to faces in Capgras delusion. Proc. R. Soc. Lond. B 264 , 1085–1092 (1997).

Collins, M. N., Hawthorne, M. E., Gribbin, N. & Jacobson, R. Capgras’ syndrome with organic disorders. Postgrad. Med. J. 66 , 1064–1067 (1990).

Enoch, D., Puri, B. K. & Ball, H. Uncommon Psychiatric Syndromes 5th edn (Routledge, 2020).

Tranel, D., Damasio, H. & Damasio, A. R. Double dissociation between overt and covert face recognition. J. Cogn. Neurosci. 7 , 425–432 (1995).

Brighetti, G., Bonifacci, P., Borlimi, R. & Ottaviani, C. “Far from the heart far from the eye”: evidence from the Capgras delusion. Cogn. Neuropsychiat. 12 , 189–197 (2007).

Coltheart, M., Langdon, R. & McKay, R. Delusional belief. Annu. Rev. Psychol. 62 , 271–298 (2011).

Coltheart, M. Cognitive neuropsychiatry and delusional belief. Q. J. Exp. Psychol. 60 , 1041–1062 (2007).

Coltheart, M. & Davies, M. How unexpected observations lead to new beliefs: a Peircean pathway. Conscious. Cogn. 87 , 103037 (2021).

Coltheart, M. & Davies, M. Failure of hypothesis evaluation as a factor in delusional belief. Cogn. Neuropsychiat. 26 , 213–230 (2021).

McCloskey, M. et al. A developmental deficit in localizing objects from vision. Psychol. Sci. 6 , 112–117 (1995).

McCloskey, M., Valtonen, J. & Cohen Sherman, J. Representing orientation: a coordinate-system hypothesis and evidence from developmental deficits. Cogn. Neuropsychol. 23 , 680–713 (2006).

McCloskey, M. Spatial representations and multiple-visual-systems hypotheses: evidence from a developmental deficit in visual location and orientation processing. Cortex 40 , 677–694 (2004).

Gregory, E. & McCloskey, M. Mirror-image confusions: implications for representation and processing of object orientation. Cognition 116 , 110–129 (2010).

Gregory, E., Landau, B. & McCloskey, M. Representation of object orientation in children: evidence from mirror-image confusions. Vis. Cogn. 19 , 1035–1062 (2011).

Laine, M. & Martin, N. Cognitive neuropsychology has been, is, and will be significant to aphasiology. Aphasiology 26 , 1362–1376 (2012).

Howard, D. & Patterson, K. The Pyramids And Palm Trees Test: A Test Of Semantic Access From Words And Pictures (Thames Valley Test Co., 1992).

Kay, J., Lesser, R. & Coltheart, M. PALPA: Psycholinguistic Assessments Of Language Processing In Aphasia. 2: Picture & Word Semantics, Sentence Comprehension (Erlbaum, 2001).

Franklin, S. Dissociations in auditory word comprehension; evidence from nine fluent aphasic patients. Aphasiology 3 , 189–207 (1989).

Howard, D., Swinburn, K. & Porter, G. Putting the CAT out: what the comprehensive aphasia test has to offer. Aphasiology 24 , 56–74 (2010).

Conti-Ramsden, G., Crutchley, A. & Botting, N. The extent to which psychometric tests differentiate subgroups of children with SLI. J. Speech Lang. Hear. Res. 40 , 765–777 (1997).

Bishop, D. V. M. & McArthur, G. M. Individual differences in auditory processing in specific language impairment: a follow-up study using event-related potentials and behavioural thresholds. Cortex 41 , 327–341 (2005).

Bishop, D. V. M., Snowling, M. J., Thompson, P. A. & Greenhalgh, T., and the CATALISE-2 consortium. Phase 2 of CATALISE: a multinational and multidisciplinary Delphi consensus study of problems with language development: terminology. J. Child. Psychol. Psychiat. 58 , 1068–1080 (2017).

Wilson, A. J. et al. Principles underlying the design of ‘the number race’, an adaptive computer game for remediation of dyscalculia. Behav. Brain Funct. 2 , 19 (2006).

Basso, A. & Marangolo, P. Cognitive neuropsychological rehabilitation: the emperor’s new clothes? Neuropsychol. Rehabil. 10 , 219–229 (2000).

Murad, M. H., Asi, N., Alsawas, M. & Alahdab, F. New evidence pyramid. Evidence-based Med. 21 , 125–127 (2016).

Greenhalgh, T., Howick, J. & Maskrey, N., for the Evidence Based Medicine Renaissance Group. Evidence based medicine: a movement in crisis? Br. Med. J. 348 , g3725–g3725 (2014).

Best, W., Ping Sze, W., Edmundson, A. & Nickels, L. What counts as evidence? Swimming against the tide: valuing both clinically informed experimentally controlled case series and randomized controlled trials in intervention research. Evidence-based Commun. Assess. Interv. 13 , 107–135 (2019).

Best, W. et al. Understanding differing outcomes from semantic and phonological interventions with children with word-finding difficulties: a group and case series study. Cortex 134 , 145–161 (2021).

OCEBM Levels of Evidence Working Group. The Oxford Levels of Evidence 2. CEBM https://www.cebm.ox.ac.uk/resources/levels-of-evidence/ocebm-levels-of-evidence (2011).

Holler, D. E., Behrmann, M. & Snow, J. C. Real-world size coding of solid objects, but not 2-D or 3-D images, in visual agnosia patients with bilateral ventral lesions. Cortex 119 , 555–568 (2019).

Duchaine, B. C., Yovel, G., Butterworth, E. J. & Nakayama, K. Prosopagnosia as an impairment to face-specific mechanisms: elimination of the alternative hypotheses in a developmental case. Cogn. Neuropsychol. 23 , 714–747 (2006).

Hartley, T. et al. The hippocampus is required for short-term topographical memory in humans. Hippocampus 17 , 34–48 (2007).

Pishnamazi, M. et al. Attentional bias towards and away from fearful faces is modulated by developmental amygdala damage. Cortex 81 , 24–34 (2016).

Rapp, B., Fischer-Baum, S. & Miozzo, M. Modality and morphology: what we write may not be what we say. Psychol. Sci. 26 , 892–902 (2015).

Yong, K. X. X., Warren, J. D., Warrington, E. K. & Crutch, S. J. Intact reading in patients with profound early visual dysfunction. Cortex 49 , 2294–2306 (2013).

Rockland, K. S. & Van Hoesen, G. W. Direct temporal–occipital feedback connections to striate cortex (V1) in the macaque monkey. Cereb. Cortex 4 , 300–313 (1994).

Haynes, J.-D., Driver, J. & Rees, G. Visibility reflects dynamic changes of effective connectivity between V1 and fusiform cortex. Neuron 46 , 811–821 (2005).

Tanaka, K. Mechanisms of visual object recognition: monkey and human studies. Curr. Opin. Neurobiol. 7 , 523–529 (1997).

Fischer-Baum, S., McCloskey, M. & Rapp, B. Representation of letter position in spelling: evidence from acquired dysgraphia. Cognition 115 , 466–490 (2010).

Houghton, G. The problem of serial order: a neural network model of sequence learning and recall. In Current Research In Natural Language Generation (eds Dale, R., Mellish, C. & Zock, M.) 287–319 (Academic Press, 1990).

Fieder, N., Nickels, L., Biedermann, B. & Best, W. From “some butter” to “a butter”: an investigation of mass and count representation and processing. Cogn. Neuropsychol. 31 , 313–349 (2014).

Fieder, N., Nickels, L., Biedermann, B. & Best, W. How ‘some garlic’ becomes ‘a garlic’ or ‘some onion’: mass and count processing in aphasia. Neuropsychologia 75 , 626–645 (2015).

Schröder, A., Burchert, F. & Stadie, N. Training-induced improvement of noncanonical sentence production does not generalize to comprehension: evidence for modality-specific processes. Cogn. Neuropsychol. 32 , 195–220 (2015).

Stadie, N. et al. Unambiguous generalization effects after treatment of non-canonical sentence production in German agrammatism. Brain Lang. 104 , 211–229 (2008).

Schapiro, A. C., Gregory, E., Landau, B., McCloskey, M. & Turk-Browne, N. B. The necessity of the medial temporal lobe for statistical learning. J. Cogn. Neurosci. 26 , 1736–1747 (2014).

Schapiro, A. C., Kustner, L. V. & Turk-Browne, N. B. Shaping of object representations in the human medial temporal lobe based on temporal regularities. Curr. Biol. 22 , 1622–1627 (2012).

Baddeley, A., Vargha-Khadem, F. & Mishkin, M. Preserved recognition in a case of developmental amnesia: implications for the acaquisition of semantic memory? J. Cogn. Neurosci. 13 , 357–369 (2001).

Snyder, J. J. & Chatterjee, A. Spatial-temporal anisometries following right parietal damage. Neuropsychologia 42 , 1703–1708 (2004).

Ashkenazi, S., Henik, A., Ifergane, G. & Shelef, I. Basic numerical processing in left intraparietal sulcus (IPS) acalculia. Cortex 44 , 439–448 (2008).

Lebrun, M.-A., Moreau, P., McNally-Gagnon, A., Mignault Goulet, G. & Peretz, I. Congenital amusia in childhood: a case study. Cortex 48 , 683–688 (2012).

Vannuscorps, G., Andres, M. & Pillon, A. When does action comprehension need motor involvement? Evidence from upper limb aplasia. Cogn. Neuropsychol. 30 , 253–283 (2013).

Jeannerod, M. Neural simulation of action: a unifying mechanism for motor cognition. NeuroImage 14 , S103–S109 (2001).

Blakemore, S.-J. & Decety, J. From the perception of action to the understanding of intention. Nat. Rev. Neurosci. 2 , 561–567 (2001).

Rizzolatti, G. & Craighero, L. The mirror-neuron system. Annu. Rev. Neurosci. 27 , 169–192 (2004).

Forde, E. M. E., Humphreys, G. W. & Remoundou, M. Disordered knowledge of action order in action disorganisation syndrome. Neurocase 10 , 19–28 (2004).

Mazzi, C. & Savazzi, S. The glamor of old-style single-case studies in the neuroimaging era: insights from a patient with hemianopia. Front. Psychol. 10 , 965 (2019).

Coltheart, M. What has functional neuroimaging told us about the mind (so far)? (Position Paper Presented to the European Cognitive Neuropsychology Workshop, Bressanone, 2005). Cortex 42 , 323–331 (2006).

Page, M. P. A. What can’t functional neuroimaging tell the cognitive psychologist? Cortex 42 , 428–443 (2006).

Blank, I. A., Kiran, S. & Fedorenko, E. Can neuroimaging help aphasia researchers? Addressing generalizability, variability, and interpretability. Cogn. Neuropsychol. 34 , 377–393 (2017).

Niv, Y. The primacy of behavioral research for understanding the brain. Behav. Neurosci. 135 , 601–609 (2021).

Crawford, J. R. & Howell, D. C. Comparing an individual’s test score against norms derived from small samples. Clin. Neuropsychol. 12 , 482–486 (1998).

Crawford, J. R., Garthwaite, P. H. & Ryan, K. Comparing a single case to a control sample: testing for neuropsychological deficits and dissociations in the presence of covariates. Cortex 47 , 1166–1178 (2011).

McIntosh, R. D. & Rittmo, J. Ö. Power calculations in single-case neuropsychology: a practical primer. Cortex 135 , 146–158 (2021).

Patterson, K. & Plaut, D. C. “Shallow draughts intoxicate the brain”: lessons from cognitive science for cognitive neuropsychology. Top. Cogn. Sci. 1 , 39–58 (2009).

Lambon Ralph, M. A., Patterson, K. & Plaut, D. C. Finite case series or infinite single-case studies? Comments on “Case series investigations in cognitive neuropsychology” by Schwartz and Dell (2010). Cogn. Neuropsychol. 28 , 466–474 (2011).

Horien, C., Shen, X., Scheinost, D. & Constable, R. T. The individual functional connectome is unique and stable over months to years. NeuroImage 189 , 676–687 (2019).

Epelbaum, S. et al. Pure alexia as a disconnection syndrome: new diffusion imaging evidence for an old concept. Cortex 44 , 962–974 (2008).

Fischer-Baum, S. & Campana, G. Neuroplasticity and the logic of cognitive neuropsychology. Cogn. Neuropsychol. 34 , 403–411 (2017).

Paul, S., Baca, E. & Fischer-Baum, S. Cerebellar contributions to orthographic working memory: a single case cognitive neuropsychological investigation. Neuropsychologia 171 , 108242 (2022).

Feinstein, J. S., Adolphs, R., Damasio, A. & Tranel, D. The human amygdala and the induction and experience of fear. Curr. Biol. 21 , 34–38 (2011).

Crawford, J., Garthwaite, P. & Gray, C. Wanted: fully operational definitions of dissociations in single-case studies. Cortex 39 , 357–370 (2003).

McIntosh, R. D. Simple dissociations for a higher-powered neuropsychology. Cortex 103 , 256–265 (2018).

McIntosh, R. D. & Brooks, J. L. Current tests and trends in single-case neuropsychology. Cortex 47 , 1151–1159 (2011).

Best, W., Schröder, A. & Herbert, R. An investigation of a relative impairment in naming non-living items: theoretical and methodological implications. J. Neurolinguistics 19 , 96–123 (2006).

Franklin, S., Howard, D. & Patterson, K. Abstract word anomia. Cogn. Neuropsychol. 12 , 549–566 (1995).

Coltheart, M., Patterson, K. E. & Marshall, J. C. Deep Dyslexia (Routledge, 1980).

Nickels, L., Kohnen, S. & Biedermann, B. An untapped resource: treatment as a tool for revealing the nature of cognitive processes. Cogn. Neuropsychol. 27 , 539–562 (2010).

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Acknowledgements

The authors thank all of those pioneers of and advocates for single case study research who have mentored, inspired and encouraged us over the years, and the many other colleagues with whom we have discussed these issues.

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School of Psychological Sciences & Macquarie University Centre for Reading, Macquarie University, Sydney, New South Wales, Australia

Lyndsey Nickels

NHMRC Centre of Research Excellence in Aphasia Recovery and Rehabilitation, Australia

Psychological Sciences, Rice University, Houston, TX, USA

Simon Fischer-Baum

Psychology and Language Sciences, University College London, London, UK

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L.N. led and was primarily responsible for the structuring and writing of the manuscript. All authors contributed to all aspects of the article.

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Nickels, L., Fischer-Baum, S. & Best, W. Single case studies are a powerful tool for developing, testing and extending theories. Nat Rev Psychol 1 , 733–747 (2022). https://doi.org/10.1038/s44159-022-00127-y

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Accepted : 13 October 2022

Published : 22 November 2022

Issue Date : December 2022

DOI : https://doi.org/10.1038/s44159-022-00127-y

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