ASCB

Join Us at Cell Bio Virtual 2021. The LARGEST online forum for cell biologists around the globe. 

Cell Bio, the joint meeting of the American Society for Cell Biology (ASCB) and European Molecular Biology Organization (EMBO), is an arena to showcase a diverse global community of the brightest minds in cell biology.

The meeting focuses on cell biology as the fundamental basis of biology as well as sessions on emerging interdisciplinary topics.

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2021 Keynote Lecture

Monday, december 6, 10:00 am est xiaowei zhuang.

Howard Hughes Medical Institute Investigator David B. Arnold Jr. Professor of Science, Professor of Chemistry and Chemical Biology, and Professor of Physics, Harvard University

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Prioritizing Inclusivity

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ASCB is committed to increasing diversity, equity, and inclusion at the Cell Bio meeting.

Read what changes are being made to increase speaker diversity in 2021 and beyond:.

  • Blind scoring review o f all abstracts for minisymposium talks. Top scoring abstracts and accompanying author demographic info are sent to minisymp co-chairs to form sessions.
  • Anyone who self-identifies as an underrepresented minority (as defined by NIH) who scores above the median score will be considered for a talk .
  • Subgroup organizers will be provided with demographic information of presenting authors listed on the abstract to help them create more diverse sessions.
  • Program committee track co-chairs can invite additional URMs to serve as a minisymposium co-chair to ensure more diversity.
  • To increase speaker diversity at the 2022 meeting, members of the Program Committee will be paired with Inclusion Buddies (who are active in DEI training and research) during the 2021 planning process. Inclusion Buddies will also lead networking roundtables at the 2021 meeting to discuss how diversity and inclusion can lead to excellence in science.

Help Shape Your Meeting

Get involved and help create the experience you want at your meeting. Find an opportunity below and apply today.

Apply for an ASCB Meeting Grant

Need assistance to attend the meeting? ASCB is providing the following grants to help offset costs to participate in Cell Bio Virtual 2021. Learn more about the available grants below:

Generously supported by National Institute of General Medical Sciences, NIH

Generously supported by Springer Nature Publishing Group

Find Your Track

Navigating the meeting has never been easier. At Cell Bio Virtual 2021, sessions will be designated by unique scientific and education tracks . Stay within a track or create your own -- the choice is yours.

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 #cellbio2021

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Meet the ‘badass’ lawyer who could blow up trump racketeering case over fani willis’ sex secrets.

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Ashleigh Merchant never stops running — and that has embattled Fulton County District Attorney Fani Willis running scared.

The “badass” Georgia criminal defense attorney, 46, who runs marathons in her spare time, will be front and center at a hearing in Atlanta Thursday that could upend the sprawling election meddling and racketeering case against former President Donald Trump and others.

In August, a Fulton County grand jury returned a 41-count indictment accusing Trump and 18 co-defendants of plotting to reverse the former president’s 2020 electoral loss in Georgia. Willis has been leading the investigation.

Then Merchant filed a bombshell motion on January 8 on behalf of her client, GOP political operative Mike Roman, 52, alleging that Willis had an “improper” and “clandestine” relationship with Nathan Wade, whom Willis appointed as a special prosecutor — and demanding that Willis’ charges against Roman be dropped.

Merchant, who was just sworn in as president of the Georgia Association of Criminal Defense Lawyers, argued that Willis should be disqualified from the case because “the district attorney chose to appoint her romantic partner, who at all times relevant to this prosecution has been a married man.”

Criminal defense attorney Ashleigh Merchant standing next to a man in a suit in a courtroom

Merchant contended that Wade, an attorney with the Marietta, Ga.-based Wade & Campbell Firm, used some of the nearly $654,000 in legal fees that he’s been paid by the Fulton County DA’s Office for his work on the Trump case to take Willis on lavish vacations to “Napa Valley, California, Florida and the Caribbean.”

Willis, 44, has admitted to a “relationship” with Wade — a personal injury lawyer with little to no experience in high-profile felony trial cases — but her office has dismissed it as “gossip” which should not derail the racketeering case.

On Thursday, Willis and Wade face a high-stakes hearing on whether their relationship is a conflict of interest, which Merchant says should lead to the end of the case against her client, and by implication, Trump and the others.

A photo of Ashleigh Merchant in court.

Willis may be forced to testify about when her relationship with Wade began, the judge presiding over the Trump case, Scott McAfee, said Monday.

It puts Merchant in the national spotlight, potentially bringing about the end of a case against Trump which some legal observers had seen as the strongest of the four criminal indictments he faces, and his remaining 14 co-defendants. Four have pleaded guilty to a range of charges.

Merchant said her work is not partisan; she just goes the extra distance for her clients, which happened when she nosed around a divorce filing by Wade’s then-estranged wife, Joycelyn — and found information that led her to believe that Willis and Wade might have financially benefited from Wade’s appointment as special prosecutor in the case.

A photo of lawyer Ashleigh Merchant in court.

“I am what I would consider a proactive defense lawyer as opposed to a reactive defense lawyer,” Merchant told The Post.

“Many lawyers only react and defend but I try to take a more proactive approach and investigate every aspect of a case.

“Many lawyers let the government do the investigation and they just try to poke holes in that but I take a very different approach. I try to use the facts and the truth to help defend my clients. And I would never take any action just to upset a case.

A photo of Georgia criminal defense lawyer Nathan Wade standing at a podium in court.

“I only take actions that are carefully investigated and have a legal basis to support them. If the government is trying to send someone to prison, I think a defense lawyer owes a duty to their clients to fully investigate every aspect of a case.”

As for preparations, “I ran this morning and it felt amazing!” Merchant told The Post Tuesday. “I actually think about cross-examinations and arguments on long runs.”

Thursday and Friday’s scheduled two-day hearing will showcase carefully honed skills, her friends said.

A photo of Joycelyn Wade in a strapless dress.

“Ashleigh’s one helluva lawyer, a real pit bull,” Dwight Thomas, 72, one of Atlanta’s most powerful and respected criminal defense lawyers, told The Post.

“I’ve known her for many years and she’s aggressive, zealous and leaves no stone unturned. She thrives on this kind of hard work and pressure and she doesn’t mind ruffling feathers.

“There’s a lot riding on this hearing and she will be more than ready for it, I can assure you.”

Longtime Georgia lawmaker Vernon Jones, a Democratic state representative-turned-vocal Trump supporter, said Merchant “is the best-kept secret in this case.”

A photo of the Marietta, GA law offices of Ashleigh Merchant and her husband, John Merchant III.

“She’s going to be the person who will bring this (Trump) case to a halt,” Jones told The Post. “She has an explosive, brilliant legal and political mind. She’s the one everyone else (the other co-defendants) are basing their legal strategy on. So goes Ashleigh, so go all the others.”

To make matters worse for Willis, Republican lawmakers in Georgia said Friday that multiple employees from the DA’s office are eager to testify against their boss in a special Senate fact-finding investigation.

She is also being investigated by Georgia’s Prosecuting Attorneys’ Qualifications Commission, and US Rep. Jim Jordan (R-Ohio) has subpoenaed her for documents about allegations that Willis fired a whistleblower from her office and misused federal funds.

A photo of Ashleigh Merchant weaing a dress and pearls.

Merchant works with her husband, John Merchant III, at a deceptively small-looking firm in an office park in Marietta, about two miles from Wade’s office. The two met at the University of Florida Law School and have two daughters.

Prior to this year, Merchant was best known for her successful defense of a man charged with murdering former beauty queen-turned-history teacher Tara Grinstead in 2005.

It was an especially tough case. Ryan Alexander Duke had confessed to killing Grinstead and burning her body, but when he took the stand, he recanted his claim and said he had been afraid of naming his friend Bo Dukes.

Rudy Giuliani, a man in a suit, speaking to the media outside Fulton County Jail, Atlanta, Georgia.

Duke got 10 years in prison for concealing a death but was acquitted of malice murder, felony murder, aggravated assault and burglary.

Her friend and fellow Georgia criminal defense lawyer Megan Grout, who is part of an informal group of female criminal defense lawyers called BAWLS — BAdass Women LawyerS — said she could “talk about Ashleigh all day. She’s gonna be hell on wheels in that courtroom Thursday.”

“She is utterly fearless and utterly dedicated,” Grout said. “All you need to know is that my daughter is in law school and she says Ashleigh is her role model — and her mother is a criminal defense attorney!”

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Criminal defense attorney Ashleigh Merchant standing next to a man in a suit in a courtroom

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The Best Biographical Movies Of 2021

Jason Bancroft

The best 2021 biopics entertain you while also giving you a better sense of who a celebrity or historical person was in real life.  Judas and the Black Messiah  gives insight into the chairman of the Black Panther Party in the the late '60s as well as the FBI's plan to take him down.  United States vs. Billie Holiday  is another 2021 biographical film that shows a historical figure going toe to toe with an entity of the federal government. These are just a few of the great biographical films that are coming out in 2021 and there are bound to be a few Oscar contenders on the list below.

But which one deserves to be at the top of the list? You get to help decide by voting up your favorite 2021 biopics and voting down the ones that you think fellow cinephiles should skip this year. Be sure to check back for new and upcoming biopics as they are added to the list once they are released.

The Eyes of Tammy Faye

The Eyes of Tammy Faye

American Underdog

American Underdog

  • # 97 of 204 on The Best Sports Movies Ever Made
  • # 53 of 68 on The Greatest Sports Drama Movies of All Time
  • # 26 of 74 on The Best Football Movies Of All Time

The United States vs. Billie Holiday

The United States vs. Billie Holiday

Judas and the Black Messiah

Judas and the Black Messiah

  • Dig Deeper... Every Oscar Winning Film Ever
  • # 329 of 460 on The Best Black Movies Ever Made, Ranked
  • # 134 of 155 on The Best Ensemble Movies Of All Time

Silk Road

  • # 24 of 25 on Great Movies About Real Female Rulers
  • # 9 of 17 on Underrated Movies About Historical Scandals
  • # 73 of 80 on The 75+ Best Recent Romantic Movies, Ranked

The Mauritanian

The Mauritanian

  • # 206 of 233 on The 200+ Best Movies Based On A True Story
  • # 125 of 216 on The 200+ Best New & Recent Drama Films, Ranked
  • # 123 of 224 on The 200+ Best Movies Directed By Women

Minamata

The Independents

King Richard

King Richard

  • # 39 of 89 on The Greatest African American Biopics
  • # 51 of 79 on Great Historical Black Movies Based On True Stories
  • # 57 of 68 on The Greatest Sports Drama Movies of All Time

Diana: The Musical

Diana: The Musical

  • # 67 of 67 on The 65+ Best Princess Movies, Ranked
  • # 30 of 62 on The Best Recent Musical Shows & Movies
  • # 45 of 54 on The 50+ Best Movies About Royalty

The Courier

The Courier

  • # 227 of 233 on The 200+ Best Movies Based On A True Story
  • # 4 of 16 on Underrated Historical Movies That Flopped At The Box Office
  • # 5 of 12 on The Most Underrated Historical Epic Movies

Respect

  • # 166 of 233 on The 200+ Best Movies Based On A True Story
  • # 48 of 89 on The Greatest African American Biopics
  • # 20 of 79 on Great Historical Black Movies Based On True Stories

Edge of the World

Edge of the World

  • # 68 of 78 on Great Period Movies Set in the 19th Century
  • # 49 of 79 on The 70+ Best New & Recent Adventure Movies, Ranked
  • # 4 of 14 on The Best Movies About British-India Colonialism, Ranked

Georgetown

Madame Claude

  • # 49 of 95 on The Best French Movies That Are Absolute Masterpieces
  • # 355 of 424 on The Greatest Movies in World Cinema History
  • # 58 of 113 on The Best Movies Directed By Women In 2021

Moffie

Percy vs. Goliath

Joe Bell

City of Lies

Charlatan

American Traitor: The Trial of Axis Sally

  • # 213 of 216 on The 200+ Best New & Recent Drama Films, Ranked
  • # 25 of 47 on The Best Al Pacino Movies, Ranked
  • # 51 of 63 on The 60+ Best Court & Law Drama Movies

The Electrical Life of Louis Wain

The Electrical Life of Louis Wain

  • # 10 of 15 on The Best Taika Waititi Movies
  • # 51 of 216 on The 200+ Best New & Recent Drama Films, Ranked
  • # 66 of 74 on The Best Movies About Art & Artists

Lansky

  • # 197 of 209 on The 200 Best Crime Movies Ever
  • # 80 of 92 on The Best Biopics To Watch About Real People
  • # 92 of 98 on The 90+ Top R-Rated Thriller Movies
  • Entertainment
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  • The Best of 2021
  • Vote on These Lists

The Best 'My Little Pony' Characters

Top 10 Innovations 2021

  • December 2021

2021 Top 10 Innovations

The covid-19 pandemic is still with us. biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges..

ABOVE: The Scientist Staff

W ith the COVID-19 pandemic dragging toward a most unwelcome third year, it’s not surprising that the biomedical community has continued to focus on diagnosing and treating the disease. The list of this year’s Top 10 Innovations winners reflects these shared goals with a couple of products that can help researchers better understand the biological realities of SARS-CoV-2 infections, interrogating cells neighboring those infected with the virus, for example, and the immune system’s reaction to it over time.

But 2021’s innovation landscape also includes laboratory and clinical products that provide a more expansive view on biology. The winners of this year’s competition include an implantable miniscope that can track activity in the brains of freely moving organisms; a microfluidic device that aims to recapitulate whole-organism physiology; and a few products that build on the emerging trend toward characterizing individual cells, with the added components of spatial information or multi-omics.

Since the last installment of our Top 10 innovations, the world has witnessed the successful deployment of multiple COVID-19 vaccines, and those are, in their own right, truly awe-inspiring innovations. In a way, it’s heartening that scientific advances have continued to occur in spaces outside of the crucial coronavirus focus. It suggests that the global biomedical apparatus is robust enough to address a pressing and pointed concern while not losing ground in fields not directly related to that crisis.

Here are the breakthroughs and advances that, thanks to the careful consideration of our panel of independent judges , have won a spot in our annual Top 10 Innovations competition.

Inscopix nVue™ System

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Weighing in at two grams, the nVue TM System is about the size of a Lego brick. This “miniaturized microscope” relies on red and green fluorescent indicators targeted to neurons to trace calcium ion influx and, in turn, the activity of two different neuronal populations in freely moving animals, according to Alice Stamatakis, director of applications at Inscopix , the company that makes the nVue. Thus far, researchers have mounted nVue on the heads of rodents, birds, and monkeys.

The miniscope offers another advantage, Stamatakis adds: longitudinal deep-brain imaging, wherein the same cells can be analyzed over multiple imaging sessions. Two-photon microscopy also allows simultaneous imaging of two neuronal populations, but it is mostly limited to the brain cortex and requires animals to be constrained by the head, compromising the study of behavior, she says. “[nVue] is going to give neuroscientists an unprecedented view into how these different brain signals communicate and talk with each other during naturalistic behaviors.” The system’s built-in data acquisition and processing software helps complete the picture.

Beyond basic biology, the dual miniscope can aid translational research for neuropsychiatric and neurodegenerative conditions, such as anxiety or Alzheimer’s disease. Kelly Tan, a neurologist at the University of Basel, Switzerland, uses the nVue system to study communication between neuronal populations in a mouse model of Parkinson’s disease. “It’s been a breakthrough for circuit neuroscience,” Tan, who highlighted the dual miniscope’s merit in a video and webinar for Inscopix, tells The Scientist .

In addition to tracking two neuronal populations, researchers can use the miniscope to juxtapose fluorescence signals from calcium influx in neurons and plasma in blood. This allows for analysis of the relationship between neuronal activity and vascular dynamics, including capillary diameter and red blood cell velocity, in the brain. Stamatakis says that Inscopix is now working to layer electrophysiology recordings and enhanced behavioral analyses into the miniscope.

Inscopix declined to provide a price for the system, explaining that the cost varies regionally.

WILEY: “The innovation is in what it allows researchers to do, which is to follow two activities in the brains of freely behaving animals over time. ”

CN Bio PhysioMimix™ OOC Multi-Organ Microphysiological System

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CN Bio released the PhysioMimix™ OOC Multi-Organ Microphysiological System in March 2021 after about 10 years of research and development through a collaboration between the Defense Advanced Research Projects Agency (DARPA) and MIT. A microfluidic organ-on-a-chip platform undergirds the PhysioMimix™ Multi-Organ System and allows scientists to connect individual organ-on-a-chip models—for example, a liver model with a gut or lung model also developed by CN Bio—for disease research and drug development, explains company CEO David Hughes.

Each chip contains millions of organ-specific human cells that can be connected in a multi-well plate format. The system mimics biological conditions by allowing media recirculation to different organ culture compartments, says Hughes; this “creates data that’s more predictive of human response” compared to insights gleaned from animal models. He adds the product is geared toward “providing more-accurate, human-relevant information to researchers in the pharmaceutical industry.”

Martin Trapecar, a Johns Hopkins immunologist and bioengineer, uses this system in his lab to study the effects of autoimmune and autoinflammatory diseases on gut and liver tissue. He says that the product presents a more realistic model to develop regenerative and personalized therapies and “eliminates a lot of the problems with studying immunology. . . . The other benefit is it gives me very granular insight into how tissue-tissue and tissue-immune interactions inform the behavior of the whole system.” According to a company announcement , CN Bio considers this technology a milestone toward an eventual “body-on-a-chip” system.

The company declined to share the price of the system.

HOCKBERGER: “[T]his product improves on the original system (launched in 2018) to enable a wider user base. . . . Cool! ”

Vizgen MERSCOPE TM

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One of two spatial genomics tools in this year’s Top 10, Vizgen ’s MERSCOPE TM is the only single-cell spatial genomics instrument currently available for purchase. Designed to conduct and analyze multiplex error resistant fluorescence in situ hybridization (MERFISH) experiments, the platform detects RNA transcripts from hundreds of genes across intact tissue and returns imaging and expression data at subcellular resolution.

The product was developed as “a new sort of research tool that gives people this unprecedented view into biological systems,” says Vizgen cofounder and director of technology and partnerships George Emanuel. “You know exactly where each transcript is with 100-nanometer accuracy.”

The Salk Institute’s Pallav Kosuri, who is using MERSCOPE TM for detailed cardiac tissue imaging, says it’s useful to work directly with the instrument, adding that while sample prep is laborious, the analysis is fully automated by MERSCOPE TM . “Everything has worked really smoothly,” says Kosuri, who did his postdoc in the Harvard University lab where the technology was developed but was not involved in the work. When he’s needed technical support, “the company has been really good at dedicating time and effort to troubleshoot with us.”

One $300,000 purchase includes the automated instrumentation, plus data visualization software and other infrastructure needed to run MERFISH experiments; reagents and probes for researchers' genes of interest cost extra. The first units were shipped in August of this year.

Kosuri says Vizgen can price the platform so high because currently, they “are the only ones doing this.” But it’s prohibitively expensive for many labs. “As an investigator, it’s super steep.”

KAMDAR: “MERSCOPE is the first commercially available high-plex, single-cell spatial genomics platform for spatially profiling gene expression across whole tissues and resolving individual transcripts with nanometer-scale resolution. The coordination of gene expression and spatial profiling opens new windows in the precise architecture of a cell. ”

Emulate Brain-Chip

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The blood-brain barrier (BBB) poses a challenge for the development of drugs that target the brain. Layers of cells that line the blood vessels of the brain evolved to help keep out toxins or other molecules that could potentially harm this vital organ, but they also block the passage of most therapeutics. With a decade-long history of developing organ-on-a-chip models, biotechnology company Emulate set out to create one that could accurately model this barrier and the structures on either side of it.

“This is our most complex and most adventurous chip because it not only has the endothelial cells, it has astrocytes, pericytes, microglia, and neurons,” says Lorna Ewart, the company’s executive vice president of science.

The Brain-Chip , which was released in December 2020, consists of two channels embedded in flexible rubber polymer. One channel is lined with stem cell–derived endothelial cells, representing blood vessel walls, and the other is lined with neurons and glia. Midway along the chip, the two channels come into contact. As fluid moves through the “blood vessel” channel, scientists can study how molecules interact with and move to the other channel—effectively crossing the BBB—and how they affect structures there.

The Brain-Chip can model both healthy and unhealthy neurological states. At Cedars Sinai in Los Angeles, developmental biologist Michael Workman and colleagues have been using patient-derived stem cell lines to create models of neurodegenerative diseases such as Parkinson’s on the Brain-Chip. “Each one of these chips is like a little patient avatar,” he says. “We do have a large interest in that personalized health and precision medicine approach, and see these microfluidic chips as a way to push more towards that.”

Emulate declined to provide a price for Brain-Chip, as it depends on end users’ requirements.

WILEY: “Very sophisticated organ-on-a-chip for brain research, providing a new and powerful approach for investigating mechanisms of neuro-inflammation and blood-brain barrier function. ”

Q Bio Gemini and Mark I

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The Gemini platform and Mark I scanner by Q Bio were introduced in April 2021 as a way to monitor patient health more comprehensively than has previously been possible in healthcare. Although it is not yet widely available, the company is rolling it out with a limited number of patients and doctors as part of a pilot program.

The Mark I prototype scans the entire body with the patient sitting, standing, or lying down, using magnetic resonance imaging (MRI), which creates high quality images without radiation—unlike X-rays, computer tomography (CT), or positron emission tomography (PET). A scan with Mark I takes only about 15 minutes, compared with traditional full-body scans that can take more than an hour. The imaging information is uploaded to the Gemini platform, along with medical records, genetics data, and traditionally acquired tests of blood, urine, saliva, and vital signs. Putting all these data together, the platform creates a “digital twin” of the patient’s anatomical structures, vital signs, and body chemistry.

By cataloging these data, small changes can be compared over time, and mathematical models could predict problems before they occur, says Jeffrey Kaditz, founder and CEO of Q Bio. This could allow doctors to efficiently triage patients’ needs based on annual scans. Currently, an annual patient membership costs $3,495 and includes a scan and consultation. Q Bio has not yet applied for FDA approval, and the company does not accept health insurance.

“Our aim is to bring a sea change in how health care is delivered on a large scale,” William Stanford, chief medical and scientific officer for the Beverly Hills Institute for Precision Medicine, says via email, adding that Gemini is the “perfect adjunct” to the facility’s multi-omic data collection efforts. The approach can be a bit cumbersome, he notes, as his patients must fly from Los Angeles to northern California, then drive to Q Bio’s facility in Redwood City for the scan—all of which takes around eight hours, round trip. The results come back two weeks later and can be sent to the patient’s primary doctor.

WILEY:  “This is a software-hardware platform to create a digital representation of a patient that can be stored and analyzed over time. The very fast (<15 min) whole-body scanner is key. This is truly a groundbreaking innovation in developing a digital framework for understanding human physiology and aging. ”

10x Genomics Chromium X

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Chromium X is 10x Genomics ’s newest instrument for single-cell analysis. Users load cells in suspension and add reagents and a partitioning oil into the microfluidic chip, which goes into the benchtop instrument. The resulting droplets, or Gel Bead-In-Emulsions (GEMs), each contain a single cell, a single barcoded Gel Bead, and a reagent, and are ready to be sequenced and used in assays offered by 10x Genomics, including gene expression analysis, epigenetic profiling, and immune cell profiling. Each GEM carries a unique barcode, allowing the user to later link results back to a single cell.

The Chromium X is the latest in a long line of products from 10x Genomics that have won top spots as Top 10 Innovations. In 2019 , the firm’s single-cell, droplet-based sequencing system made the Top 10, and in 2020 , the Chromium Single Cell Multiome ATAC + Gene Expression assay won a spot. Chromium X improves on previous products because of its flexibility, says Jens Durruthy Durruthy, associate director of product management–single cell at the company. “Chromium X is scalable and can be used both for low-throughput assays, with hundreds of cells, as well as for high-throughput assays with up to one million cells.”

Sisi Chen, director of the Single-Cell Profiling and Engineering Center at Caltech, notes in an email to The Scientist that the high-throughput capability of the Chromium X is essential to her research. She uses the Chromium X, which was launched in July 2021, to explore how therapeutic compounds influence the human immune system, and the system allows her to simultaneously stimulate 1 million immune cells, each with one of up to 100 different therapeutics, and track their responses. “We want to profile the [immune] system across hundreds to thousands of different unique conditions,” says Chen.

In the US, Chromium X is available from $100,000. With high-throughput assays, users can get the cost per run down to 2 cents per cell.

HOCKBERGER:  “10X Genomics is back with a new high-scale, high-resolution version of its flagship instrument, Chromium. The latest product democratizes access to high throughput, single-cell analysis of gene expression and immune profiling by offering it at an affordable price. Well done! ”

The Native Antigen Company  SARS-CoV-2 Neutralization Assay Development Kits

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A few years ago, the World Health Organization added “ Disease X ” to its short list  of emerging diseases—a placeholder for unknown pathogens with pandemic potential. Researchers at The Native Antigen Company , a UK-based group that designs reagents for infectious disease research, speculated in November 2019 that one candidate might be a coronavirus, one that would likely arise in Asia and spread from animals. Then came SARS-CoV-2.

By spring 2021, The Native Antigen Company had developed a coronavirus neutralization assay to determine a serum sample’s level of antibodies that bind, and therefore neutralize, the virus. The assay uses synthetic versions of the SARS-CoV-2 spike protein’s receptor binding domain and its target, the mammalian ACE-2 receptor, and pairs them with an ELISA-based platform that quantifies the neutralizing ability of the antibodies via a color change, explains the company’s Commercial Director, Andrew Lane. Researchers can use this tool to probe how patients respond to infection and to study vaccine efficacy, among other applications, he adds.

The kit doesn’t require live virus and is speedy compared to methods that use benign, engineered viruses called pseudoviruses, according to Lane. Since the first kit was released in April 2021, the company has produced assays for five variants. “It’s a bit like a plug-and-play system for us. We can make kits with different variants quite quickly,” Lane says. Each kit analyzes 960 samples and costs $2,728.

“Overall, we’re very happy with its response,” says Matthew Edmans, a postdoctoral researcher at the University of Oxford who is using the assay to study how patients on immunomodulatory drugs respond to SARS-CoV-2 infection. Edmans also uses pseudoviruses, but agrees they can be “quite complicated,” while The Native Antigen Company’s assay “is just a lot faster and more straightforward to run.”

KAMDAR: “Needed to assess the protection and longevity of patient immunity to emerging variants. This is all done without the need for BSL3 facilities, thereby providing a safer alternative for these critical public health questions. ”

Mission Bio Tapestri Single-cell Multi-omics Solution

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Mission Bio ’s Tapestri Single-cell Multi-omics Solution , launched in October 2020, is a process for single-cell analysis that allows users to consider DNA sequence and proteomic information simultaneously—an innovation on traditional setups that required separate systems to analyze nucleic acids and proteins, which could therefore not be correlated at the single-cell level. Mission Bio’s Tapestri Precision Genomics Platform earned a spot in The Scientist ’s Top 10 Innovations of 2018 and was the first high-throughput instrument for single-cell DNA sequencing sample prep. “We were then able to add other analytes, such as proteins, subsequently,” says Adam Sciambi, Mission Bio’s cofounder and senior director of technology & systems.

With the Tapestri Single-cell Multi-omics Solution, assays for DNA and protein are combined in a single integrated workflow that can analyze up to 10,000 cells at a time. The Tapestri instrument uses microfluidics to capture individual cells in droplets that contain both the reagents for DNA sequencing and antibodies for tagging cell-surface proteins, plus a barcoding bead. “The result of our platform is every piece of DNA comes out labeled as telling you which droplet it came from,” says Sciambi. The DNA is then sequenced using next-generation sequencing, and the cells’ surface proteins are characterized. Mission Bio declined to disclose the cost of the platform.

Molecular biologist Jan Cools of the VIB-KU Leuven Center for Cancer Biology in Belgium has used the Tapestri platform to investigate mutations underlying acute lymphoblastic leukemia (ALL). He is now planning to use Mission Bio’s Tapestri Single-cell Multi-omics Solution to obtain additional information on cell-surface markers, a setup he says will be especially useful for studying a different type of blood cancer, acute myeloid leukemia (AML). In AML, some leukemia cells are known to be more stem cell–like, while others are more differentiated, a difference that could be captured by looking at cell surface markers and sequencing data, Cools says.

KAMDAR: “T apestri is the only commercialized multiomics platform capable of analyzing DNA and protein simultaneously from the same sample at single-cell resolution. The real power is the ability to generate correlation data between the genome, transcriptome and the proteome. ”

Cardea Bio  CRISPR-SNP-Chip

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Cardea Bio ’s CRISPR-SNP-Chip is the first device capable of detecting single base differences in DNA without generating millions of copies of the DNA first. “We can do DNA tests without the need of a DNA lab,” explains Cardea CEO Michael Heltzen.

The latest of Cardea’s biological processing units, or BPUs (analogous to the CPUs that underlie computer technologies), the chip is an updated version of the company’s CRISPR-Chip™ , which already allowed for rapid, amplification-free detection of large, disease-associated sequence variants and transgene insertion success, among other applications, says Keck Graduate Institute biomedical engineer and Cardea Chief Scientific Officer Kiana Aran. She explains that both versions are composed of a CRISPR-Cas system tethered to a graphene transistor. When the Cas enzyme’s guide RNA binds to the correct sequence, it pulls the DNA closer to the transistor. Because DNA is negatively charged, this generates an electronic signal in the semiconductive graphene that can be digitally read. “You let the biology do what it’s good at, and then you sense it with our sensor,” says Aran. “We use the power of biology as technology.”

Giving the chip the ability to detect single nucleotide polymorphisms (SNPs) involved replacing the Cas enzyme with a more sensitive version and upgrading the data analysis, Aran notes. In an April paper , the team demonstrated the updated chip’s ability to detect SNPs that underlie sickle cell anemia and amyotrophic lateral sclerosis (ALS), though the potential applications are bounded only by creativity, the authors write. Its most immediate use is for quality control of gene editing for medicinal or agricultural purposes, Aran says.

Those interested in using the chips can apply for Cardea’s partnership program . While the exact cost depends on the application, Heltzen notes that the price per chip has dropped to tens of dollars from the thousands they were a few years ago.

HOCKBERGER: “Another game changer for clinical diagnosis. ”

Resolve Biosciences Molecular Cartography TM  Single-Cell Spatial Analysis Service

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Spatial biology addresses how cells function in the context of tissues. While single-cell sequencing methods have permitted many advances in this field, they lack the resolution to provide 3D data at subcellular scales, and involve destroying the tissue sample. Resolve Biosciences ’s Molecular Cartography™ Single-Cell Spatial Analysis Service , the second spatial genomics tool in this year’s Top 10, instead offers fluorescence in situ hybridization (FISH) to create high-resolution images of what genes are expressed—down to the subcellular level.

The mail-in service, launched June 2 in North America and Europe, detects individual RNA transcripts inside intact tissues. “We can interrogate pretty much any tissue you can put on the slide,” says company CEO and cofounder Jason Gammack, adding that the platform can analyze 24 samples simultaneously. Costs depend on project specifications, but most customers can generate sample data for around 4,000 euros, he says. That includes a meeting with a customer technology adviser to define project scope and a sample prep kit in a return-mail box. Researchers receive a summary report and data on their chosen genes—the platform lets researchers visualize up to 100—in about four weeks; the adviser also helps researchers interpret the data.

Jean-Christophe Marine of the VIB-KU Leuven Center for Cancer Biology has used the service through an initiative at his institution that supports early access to new technologies. “We are very satisfied by the data,” says Marine, who studies intratumor heterogeneity in melanoma. “[The] vast majority of the probes worked, and . . . you have a nice resolution.” The service is well-priced, he adds, although his team has only been able to analyze mouse samples due to restrictions on mailing human samples.

In the future, Resolve Biosciences plans to make the whole Molecular Cartography TM platform available for researchers to operate themselves. The company will expand what types of molecules can be imaged, too, Gammack says, with proteins up next. “We’re actively developing that chemistry right now.”

KAMDAR: “The technology has potential to help researchers better understand human brain development, cell type evolution, and how the SARS-CoV-2 infection affects neighboring cells over time. ”

bio an 2021

Philip Hockberger

Associate professor of neuroscience in the Feinberg School of Medicine at Northwestern University. He is recognized internationally for his leadership role in research core facilities and for promoting the careers of core scientists.

bio an 2021

Managing partner at Domain Associates, a health care–focused venture fund that creates and invests in biopharma, device, and diagnostics companies. She began her career as a scientist and pursued drug discovery research at Novartis for nine years.

bio an 2021

H. Steven Wiley

Senior research scientist and laboratory fellow at Pacific Northwest National Laboratory. He published some of the earliest computer models of receptor regulation and is known for developing a variety of quantitative biochemical and optical assays as a basis for validating computational models of cell processes.

Editor’s Note: The judges considered dozens of entries submitted for a variety of life science products by companies and users. The judging panel evaluated submissions with only basic instructions from  The Scientist , and its members were invited to participate based on their familiarity with life science tools and technologies. They have no financial ties to the products or companies involved in the competition. In this issue of  The Scientist , any advertisements placed by winners named in this article were purchased after our independent judges selected the winning products and had no bearing on the outcome of the competition.

Correction (December 1): The original version of this article stated that DNA is positively charged, when in fact it is negatively charged.  The Scientist  regrets the error.

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Patton Oswalt in A.P. Bio (2018)

A former philosophy professor who takes a job teaching advanced placement biology uses his students to get back at the people in his life who have wronged him. A former philosophy professor who takes a job teaching advanced placement biology uses his students to get back at the people in his life who have wronged him. A former philosophy professor who takes a job teaching advanced placement biology uses his students to get back at the people in his life who have wronged him.

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A.P Bio: Victor Attends A House Party

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‘Star witness’ mostly silent in hearing to disqualify Fani Willis

ATLANTA — A man billed as the “star witness” in the case to disqualify Fulton County District Attorney Fani T. Willis (D) took the stand Friday and acknowledged he exchanged text messages about Willis with the defense attorney who first raised allegations that Willis was engaged in an improper personal relationship with the outside attorney she appointed to lead the case against Donald Trump .

But Terrence Bradley, a former law partner of special prosecutor Nathan Wade, repeatedly declined to answer questions under oath about what he knew about the romantic relationship between Willis and Wade. Bradley, who previously represented Wade in his ongoing divorce, cited concerns he might violate attorney-client privilege and could be disbarred.

However, in a dramatic moment, an attorney for Bradley later asked Fulton County Superior Court Judge Scott McAfee if his client could be released from that privilege after a prosecutor claimed during cross-examination that Bradley and Wade ended their legal partnership after Bradley was accused of sexually assaulting an employee and a client. Prosecutors implied this raised questions about Bradley’s credibility as a witness and whether he had ill will toward Wade.

Bradley, who emphatically denied he had sexually assaulted anyone, admitted the employee’s claims had led him to sever his partnership with Wade. He testified that he still considered Wade to be “a friend.”

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The revelation, which came near the end of a two-day evidentiary hearing on misconduct claims against Willis, led McAfee to abruptly end Bradley’s testimony. McAfee said he would meet with Bradley and his attorney in a private hearing to consider whether Wade’s attorney-client privilege claim with Bradley had been pierced and whether Bradley could be forced to answer questions about Willis and Wade.

McAfee will ultimately have to decide if the prosecutors’ relationship created a conflict of interest or the appearance of one — and if Willis’s office should be removed from the case or if any of the charges should be dropped against Trump or his allies, who are accused of criminally conspiring to try to overturn the 2020 presidential election in Georgia . That decision probably won’t come soon: McAfee said Friday he will schedule another hearing for late next week or the following for closing arguments. The scandal has threatened to imperil the criminal case against the former president, and Willis’s allies worry it has hurt her credibility.

Bradley’s silence on what he knew about Willis and Wade’s relationship , including when it began, came as Ashleigh Merchant, an attorney for co-defendant Mike Roman, presented text messages and an email showing that she had been communicating with Bradley since September when she began investigating allegations of an improper romantic relationship between Wade and Willis.

The exchanges presented in open court suggested that Bradley had been a key source for Merchant, who has claimed that Willis was already in a romantic relationship with Wade when she appointed him to lead the election case.

Bradley initially testified he did not recall conversations with Merchant, claiming that he had communicated with her through a “third party.” But he eventually acknowledged that he spoke to Merchant by phone and later exchanged text messages as she sought to confirm rumors that Willis and Wade were a couple.

In one message introduced as evidence by Merchant, she had messaged Bradley asking if he knew of anyone who would give her “an affidavit … about the affair.”

Examining his own phone, Bradley confirmed that he responded, “No one would freely burn that bridge.”

Bradley also confirmed that he texted with Merchant about trips Willis and Wade took together and how Wade had used his corporate card to pay for them. Bradley confirmed Merchant had sent him a copy of the Jan. 8 motion she filed that first detailed allegations of an improper relationship between Willis and Wade.

“Looks good,” Bradley texted Merchant in response to her filing — a message he confirmed under oath.

In a motion last week, Merchant claimed Bradley would “refute” claims by Willis and Wade that their romantic relationship did not begin until after Nov. 1, 2021 — the date he was appointed to lead the Trump investigation. But Bradley repeatedly testified that he had “no personal knowledge” of when their relationship began — a claim that visibly frustrated Merchant and other defense attorneys who strongly implied that Bradley had relayed different information in his earlier communications with Merchant.

Special prosecutor Anna Cross, who is leading efforts to help Willis retain control of the case, accused Merchant and Bradley of trading “gossip” and “hearsay,” as lawyers from both sides battled for hours over what Bradley could and could not testify about. The back-and-forth came after Bradley, who briefly testified Thursday morning, failed to appear Friday morning for scheduled testimony. His attorney claimed that Bradley had a medical appointment.

But McAfee, a typically opaque presence on the bench, was visibly annoyed, telling the attorney that Bradley had not previously informed the court about a medical visit and warned that he was in potential violation of his subpoena.

One day earlier, Willis testified and angrily sparred with Merchant and other defense attorneys whom she accused of spreading “lies” about her and her relationship with Wade. Willis had been scheduled to return to the witness stand Friday morning for prosecution questioning, but as the hearing got underway, Cross announced she had no questions for Willis and the district attorney’s appearance was concluded.

Instead, prosecutors called other witnesses to bolster Willis’s claims on the stand, including her testimony that Wade was not her first choice to lead the investigation. Former Georgia governor Roy Barnes (D) testified about an October 2021 meeting where he turned down Willis when she asked him to take on the case. He said he had concerns about income and potential threats that came with taking on the high-profile case against a former president.

“I have mouths to feed at a law office and that I could not, I would not do that,” Barnes testified. “I’d lived with bodyguards for four years, and I didn’t like it. I wasn’t going to live with bodyguards for the rest of my life.”

Prosecutors also called Willis’s father, John Clifford Floyd III, a former criminal defense attorney who at one point lived with his daughter in her Atlanta-area home. Floyd testified that Willis moved out at his urging when threats against her began to escalate, while he remained, taking care of the property — a brand-new home that his daughter had built only to be forced to leave it.

“Somebody needed to protect the house,” Floyd said, recalling how he once cleaned “the b-word and the n-word” that had been spray painted on the house, not telling his daughter about it. The threats soon became too much and now the house is “uninhabitable,” he testified.

Floyd said under oath that he had not met Wade until last year and didn’t learn of his daughter’s relationship with him until seven weeks ago — when the rest of the world did. While the two are extremely close, Floyd said he and his daughter don’t talk to each other about their romantic lives. “I haven’t confided in her about mine before — when I had one,” he said.

At Thursday’s hearing, defense attorneys seized on comments Willis and Wade made about her repaying him for trips in cash, exchanges for which they did not have documentation. Trump has accused Willis in social media posts of not having actually made those repayments and, therefore, financially benefiting from appointing Wade to the case.

But Floyd tried to explain to the court Friday that he taught Willis to always have large amounts of cash on hand in her home. He said he owned multiple safes of his own and had proudly purchased his daughter “her first cash box,” where he encouraged her to always keep at least six months’ worth of money.

He said the advice was driven by his own experience, where people had sometimes refused to take credit cards or travelers checks from him because “of the color of my skin.”

“Excuse me, your honor, I’m not trying to be racist. But it’s a Black thing, okay?” Floyd said. “I was trained, and most Black folks, they hide cash or they keep cash.”

Gardner reported from Washington. Marianne LeVine and Maegan Vazquez in Washington, Yvonne Wingett Sanchez in Phoenix, Sarah Ellison in New York and Patrick Marley in Madison, Wis., contributed to this report.

More on the Trump Georgia case

The latest: Fulton County District Attorney Fani T. Willis (D) has been investigating whether Trump and his associates broke the law when they sought to overturn Trump’s 2020 election loss in Georgia . Willis testified in a hearing challenging defense attorneys who she said spread “lies” about a personal relationship she recently admitted to with Nathan Wade , the prosecutor she appointed. Here’s how it could derail the Trump Georgia case .

Status of the case: Four of Trump’s co-defendants have pleaded guilty in the Georgia election case. Trump previously entered a plea of not guilty . The case does not currently have a scheduled trial date.

The charges: Trump was charged with 13 counts, including violating the state’s racketeering act . Read the full text of the Georgia indictment . Here’s a breakdown of the charges against Trump and a list of everyone else who was charged in the Georgia case . Trump now faces 91 total counts in four criminal cases .

Historic mug shot: Trump surrendered at the Fulton County Jail on charges that he illegally conspired to overturn his 2020 election loss . Authorities released his booking record — including his height and weight — and mug shot .

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Who Is Usher's Wife? All About Jenn Goicoechea

Usher and Jenn Goicoechea made their first public appearance as a couple in 2019 and wed in February 2024

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Usher and Jennifer "Jenn" Goicoechea are married!

On Feb. 8, 2024, just days ahead of Usher's Super Bowl halftime show in Las Vegas, the singer and Goicoechea obtained a marriage license in Clark County, Nevada. Four days later, multiple sources confirmed to PEOPLE that the couple tied the knot that weekend.

The Grammy -winning performer — whose real name is Usher Raymond IV — and the record executive first sparked dating rumors when they were photographed together at producer Keith Thomas' 40th birthday party in June 2019.

Usher and Goicoechea welcomed their first child together, daughter Sovereign Bo , in 2020, followed by their son, Sire Castrello , in 2021. Usher also shares two sons , Usher V and Naviyd Ely, with his ex-wife, Tameka Foster.

"I have an amazing partner, a support system," Usher told PEOPLE of his now-wife in November 2023. "We have an amazing dynamic. I'm very happy, very fortunate to have an incredible friend, not just a partner. She's my best friend and I love her ."

He opened up more about his commitment to Goicoechea mere days before the two tied the knot, telling PEOPLE in February 2024, "Listen, when you find someone that you know is a great partner, of course it is an honor and a pleasure to be able to share life with someone who wants to share it with you and loves you, who you are."

He continued, "We've obviously made a commitment to life for life together because of our children," he added. " It wouldn't be odd for us to get married. We already did here. You know what I'm saying? I really do feel like I have an amazing partner that I respect."

So, who is Usher's wife? Here's everything to know about Jennifer "Jenn" Goicoechea and her relationship with the singer-songwriter.

She grew up in Miami

Goicoechea, who was born to an Italian mother and a Puerto Rican father, grew up in Miami. After high school, she continued her education in her home state.

According to her LinkedIn , she studied recording arts at Full Sail University in Winter Park, Florida, starting in 2003.

She got her start in entertainment working with her mother

Goicoechea first started off in the entertainment industry by shadowing her mother, Barbara Goicoechea.

Barbara has been the director of operations at ACT Productions , a Miami-based event and multimedia production company, since 1988. Working with her mother gave Goicoechea the chance to land a position working as an assistant for singer Ciara , which kicked off her career in entertainment.

On Mother's Day 2020, Goicoechea posted a throwback photo of herself as a child and penned a tribute to her mom.

"Happy Mother's Day to the Strongest woman I know. Barbara, i couldn't have prayed for anything better... Your are truly Amazing! Love Boogs ❤️," she wrote in the caption.

She's a music executive and former manager

When Goicoechea relocated from Florida to the West Coast, she began representing artists under her management company, Boogs'N'Effect Management. One of her first artists was KING (née Keisha Rain).

According to her LinkedIn, Goicoechea worked at ASCAP as the director of rhythm & soul starting in January 2014. The nonprofit membership organization includes songwriters, composers and publishers and helps its members receive fair compensation for public performances and distributing royalties.

"Having strong organizational skills, event planning abilities, being able to identify burgeoning talent early on while staying current and involved on the music scene and keeping my ear to the pulse is what helped me get to where I am today," Goicoechea told Rolling Out in November 2015, adding that adaptability had been essential to her success in the industry.

In December 2016, Goicoechea announced her exit from the organization on Instagram . She thanked her colleagues and ASCAP executive Nicole George-Middleton in the caption: "I just wanted to Thank my ASCAP Family for everything… @mrsngm I will always be in debt to you. You gave a girl from Miami a shot."

After leaving ASCAP, Goicoechea became the senior vice president of A&R at Epic Records, a label owned by Sony Music Entertainment. She often promotes Epic artists on her Instagram , including Lil Harold, DDG , 21 Savage , Beam and more.

She went public with Usher in 2019

Having worked in the music industry for years, Goicoechea crossed paths with Usher several times before they became romantically involved. In March 2016, she shared a photo of herself whispering in his ear at an undisclosed event. A few years later, in March 2018, she posted a throwback photo with him and other male creatives, including producer Bryan-Michael Cox, captioned simply: "Boys Club."

However, it wasn't until after they were photographed attending Thomas' birthday celebration in Atlanta in June 2019 that rumors swirled of a possible romance between the two.

They were then spotted kissing backstage at a concert at the Hollywood Bowl in October 2019.

Photographer Jennifer Johnson shared a snapshot from the night on Instagram, writing: "'Cause she's such a good kisser! 💋Caught a rare moment with @usher backstage the other day. I stay catching moments like these boys be catching feelings!"

In December 2019, the newly-minted couple also cozied up at Sean "Diddy" Combs ' 50th birthday party in Los Angeles, per The Atlanta Journal-Constitution . Usher also performed at the star-studded event .

She was a back-to-back Billboard honoree

Goicoechea was named one of Billboard's R&B/Hip-Hop Power Players in 2020 alongside several Epic Records colleagues.

After she was recognized again in 2021 by the outlet, Goicoechea expressed her gratitude on Instagram , giving a shout-out to her bosses.

She wrote, "Honored to be on this years R&B/Hip-Hop Power Players list!! Thank you @billboard for the acknowledgement ... BIG Thank You @iamsylviarhone and @ezekiellewis for the opportunity to do what I love everyday #blessed."

She shares two children with Usher

Usher Instagram

After a source confirmed to PEOPLE in September 2020 that the couple were " thrilled to be expecting " their first child, Usher shared the news himself on Good Morning America on Sept. 4.

While announcing his 2021 Las Vegas residency , he said: "Babies always bring such joy to a family and [I'm] really excited for my young one — well, my bean's arrival."

Two weeks later, Usher and Goicoechea welcomed their daughter , Sovereign Bo, on Sept. 24, with Usher confirming her arrival a few days later on Instagram .

"We are feeling blessed and full of love with the arrival of our beautiful baby girl, Sovereign Bo Raymond. “Isn’t She lovely” by Stevie Wonder on repeat ❤️ ❤️ ❤️," the proud dad wrote.

During an appearance at the iHeartRadio Music Awards in May 2021 — which Usher hosted — Goicoechea showed off her growing baby bump in a fitted black gown, subtly announcing she and the singer were expecting again.

Their son, Sire Castrello, arrived on Sept. 29, 2021. Usher announced his birth the following month on Instagram , writing:  "Hi my name is Sire Castrello Raymond … I am the newest addition to the Raymond crew. I was born Sept 29 2021 at 6:42pm weighting 7lbs 13oz. Hear me roar … A.K.A Ra Ra . 👶🏽 ♎️ Gang."

In her own post , Goicoechea shared the emotional backstory behind her son's name, explaining that her grandfather, Champ Castrello, died at age 105, shortly before she gave birth.

"Champ was the strongest, bravest, family oriented, funny and kindest man I know.. (other than my baby father lol)," she captioned the black-and-white photo of her with baby Sire. "I couldn't ask for a better example of how a man should be! He was the definition … it was only right we keep his name alive."

She received a birthday surprise from Usher during his Las Vegas residency

While Usher has made headlines at his Vegas residency for roller skating and serenading concertgoers like Kim Kardashian , fans were equally excited to see Usher treat Goicoechea to an early birthday surprise on Oct. 12, 2022, per the Las Vegas Review-Journal .

Usher escorted Goicoechea to a cocktail table on the stage and the two enjoyed an impromptu date night in front of the crowd, toasting for her birthday and sharing a kiss.

In July 2023, the "OMG" singer gave her another shout-out during his residency. After thanking all of the staff and performers, he thanked Goicoechea, saying: "My GOAT... my love, Jenn."

She supported Usher when he received his honorary degree

On May 13, 2023, Berklee College of Music in Boston presented Usher with an honorary doctorate. Goicoechea was among those in attendance cheering Usher on, along with his mom Jonetta Patton , longtime collaborator Jermaine Dupri, brother J.Lack and his two oldest sons.

Usher posted a series of photos and clips on Instagram from the commencement, referencing his 1997 hit single "Nice & Slow" in the caption.

"They call me D-o-c-t-o-r R-a-y-m-o-n-d 🎓😏🙏🏾," he wrote alongside snaps with his loved ones while wearing a cap and gown. "Thank you @berkleecollege for honoring me and presenting me with a Doctor of Music degree. I'm so grateful for this opportunity to share a message to the next generation of artists, producers, vocalists, arrangers, dancers and more."

She and Usher got married in Las Vegas in February 2024

Marc Patrick/BFA.com/Shutterstock

Usher and Goicoechea obtained a marriage license ahead of the singer's halftime performance at the 2024 Super Bowl. Days later, multiple sources confirmed to PEOPLE that the couple did, indeed, get married that weekend.

After the game, Usher was photographed wearing a gold band on his left ring finger and a black tuxedo over a white coat. Goicoechea was at his side in an all-white pantsuit.

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bio an 2021

Pivot Bio, Iowa State collaborate for new, $14 million ag research and education facility

From left to right: Roger Underwood, Chairman of the Board of Directors at Pivot Bio; Wendy Wintersteen, President of Iowa State University; Chris Abbott, Pivot Bio CEO; Governor Kim Reynolds; and Iowa Secretary of Agriculture Mike Naig attend a ribbon-cutting for Pivot's new $14 million facility in Ames.

A collaboration between an agriculture company and Iowa State University has birthed a $14 million, 36,000-square-foot education and research facility in Ames.

Pivot Bio , a sustainable agriculture company focused on microbial nitrogen, opened its Customer Success Center last week in the Iowa State University Research Park .

Pivot Bio delivers patented crop nutrition technologies to framers to improve grow operations. The company's nitrogen is weatherproof and does not contribute to nitrous oxide poison by delivering nitrogen to plants without the negative impacts of synthetic fertilizer.

“We’re celebrating a milestone for the farmers we serve as we open our new Customer Success Center in the heart of the Corn Belt,” said Chris Abbott, Pivot Bio CEO said in a company press release last week. “More than a building, this new center is an embodiment of our collective commitment to reshaping agriculture for the better."

The Customer Success Center is Pivot Bio's third building in the Research Park in the last five years. Planning for the company's newest facility began about a year and a half ago, and construction started in the winter of 2022.

Amanda De Jong, head of government affairs and policy engagement at Pivot Bio, said the company's continued growth proves its success.

"Over the course of the last five years, (our expansion) demonstrates the commitment of our farmers and the success and growth that we've seen from the company and our ability to retain and attract talent in Ames," De Jong said. "It's been a great home."

More: How wheat it is: Great Harvest Bakery and Café adds a special twist to the bread-making process

Ag-centric education and research

The Customer Success Center will serve as a commercial hub for Pivot Bio's microbial nitrogen products, as well as an education and collaboration center for farmers, researchers and industry experts. The facility's main purpose, De Jong said, is for education and training for their network of farmers.

"(Our customers) are the hero of our story, and we want to be able to have a convening space for them where we can learn and share ideas," De Jong said. "We're calling it a customer success center because it really is about service to the growers. It's a great facility to be used as a convening space."

The building also includes about 15,000 square feet of open high bay that will support work on agronomy equipment, including hands-on training and calibration for seed treatment equipment.

More: The Ames Community School District has tapped a search firm to help hire a new superintendent

Pivot Bio, Iowa State celebrate partnership

Pivot's newest facility joins several other businesses and resources at the Research Park just south of the Iowa State campus, enabling innovation in a wide variety of fields.

“The Customer Success Center is a perfect fit for Iowa State’s vibrant innovation ecosystem,” Iowa State University President Wendy Wintersteen said in last week's press release. “The collaborative partnership between Pivot Bio and Iowa State University not only drives economic growth and supports hardworking farmers, but also reinforces Iowa’s central role in shaping a more innovative and sustainable future for agriculture.”

Pivot Bio and Iowa State have collaborated successfully in the past, partnering on an independent research study in 2022. Working with the Iowa Nutrient Research and Education Council, the study demonstrated how Pivot Bio’s microbial nitrogen product can increase biomass in corn plants, contributing to healthier and more productive crops.

Story Construction also partnered with Pivot to help build the Customer Success Center.

"They took our vision and our needs, and they created a reality and home that will serve our growers and our employees for years to come," De Jong said. "We could not be more pleased with how the process went and the support we received from the university, Story Construction and all the partners."

It's a really great space to convene partners - business partners, farm partners, Iowa State research partners come together and work on solving some of agriculture's biggest challenges.

More: Ames resident arrested on three counts of animal neglect for hoarding 27 cats

Celia Brocker is a government, crime, political and education reporter for the Ames Tribune. She can be reached at [email protected] .

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Harold Franklin became Auburn’s first Black student on this day in 1964. Why couldn’t he graduate?

S ixty years ago today, Harold Franklin became the first Black student to attend Auburn University – though he would not receive his degree until decades later, in 2020.

Isolated and under heavy guard, Franklin arrived on Auburn’s campus on Jan. 4, 1964. Officials had previously rejected his application, but with the help of the NAACP, he successfully sued the college in 1963, making Auburn the third state college to desegregate.

Franklin died in 2021 at the age of 88.

“I won two cases against them,” Franklin told AL.com in a 2019 interview . “I was a 31-year-old married agitator. George Wallace was governor. I don’t have to tell you what he was like.”

Franklin, a Talladega native, had recently graduated from the historically Black Alabama State College and, inspired by the late Supreme Court Justice Thurgood Marshall, had dreams of attending law school one day.

It was attorney Fred Gray who initially encouraged Franklin to work on a master’s at Auburn – but it would take some convincing.

“I don’t want to go to a cow college,” Franklin’s son, Harold Franklin Jr., recalled his father telling Gray at the time.

But eventually Franklin agreed to join Gray’s class-action suit, and after two years of court proceedings, he would become the first Black student to successfully register at the school.

“It proved to him something that he already knew,” Franklin’s nephew, Melvin Bolton, told the school’s alumni association in 2021. “And that was that whatever he set his mind to, he could achieve.”

An ‘incomplete’ year

Franklin’s time on campus was anything but normal.

On his first day of school, Gov. George Wallace ordered troops to stop him from registering. An FBI agent escorted him to the registrar, and he was assigned to one wing of a dormitory, where he lived alone until other Black students slowly began to enroll.

A semester later, he shared a bathroom with Willie Wyatt Jr. and Anthony Lee, the first Black students to enroll at Auburn as undergraduates. Wyatt and Lee applied in the fall of 1964, but were not initially accepted because they didn’t have housing, Wyatt told AL.com in a recent interview.

Lee attended all four years and became the school’s first Black graduate. Wyatt, like Franklin, left Auburn after a year and finished his degree at Tuskegee University.

“College life to me was not only supposed to be an academic experience but a social experience,” Wyatt said. “And at Auburn you would have no social experience.”

Franklin told the Washington Post years later that white students refused to sit next to him in his classes. He also struggled to gain support from his professors, he said.

Franklin wanted to write about the civil rights movement for his thesis, but revealed in a 2019 interview with AL.com that faculty urged him against it because the topic was “too controversial.”

He later changed his focus to the history of Alabama State College, his alma mater. But Auburn officials repeatedly rejected his submissions.

He submitted draft after draft, and faculty kept sending it back for trivial reasons, Franklin recalled. One professor, he said, said his work had to be perfect because he was Black and many people would read it.

“Finally I said, ‘Hell, what you’re telling me is I won’t get a degree from Auburn,’” Franklin told AL.com .

After leaving Auburn without graduating in 1965, Franklin received his master’s degree from the University of Denver. He later went on to pursue a long career teaching history at numerous colleges before his retirement in 1992.

In 2001, nearly 37 years after his enrollment, Auburn awarded Franklin an honorary Doctor of Arts, but the school never addressed the racism that prevented him from earning the degree he had actually applied for.

“It was a really nice gesture,” Keith Hébert, an associate professor of history at Auburn, told AL.com in 2021. “For Harold, the honorary degree was nice. He displays it. It’s on the wall. He’s Dr. Harold Franklin. But there was an incompleteness. He had earned all the credits, he did all the courses, he had written the thesis.”

Getting his degree

According to Hébert, officials did not learn about Franklin’s rejected master’s thesis until after his 2019 interview with AL.com , where Franklin discussed his experiences at the school and shared his thoughts on Gov. Kay Ivey’s blackface yearbook photo. Ivey was a freshman at the college when Franklin enrolled.

A couple of months later, Hébert and several other Auburn faculty went to visit Franklin at his home in Sylacauga, where they asked him if he still had his thesis. He reached across the sofa and let them read it. After 54 years, he always had it close by, he told them.

“We tried to evaluate it from the era it was written, which was 1969, to read what was approved that year,” Hébert, who would later chair Franklin’s thesis committee, told AL.com in 2021. “He had written a well-researched master’s thesis. He had, more than 50 years earlier, fulfilled all requirements. We organized a defense. It’s shameful that it had to take this long.”

Franklin successfully defended his master’s thesis on Feb. 19, 2020. Attached to the approval was a formal apology, Hébert said.

“I’m honored,” Franklin, then 87, told AL.com at the time. “I’m happy they finally decided after all these years. I’ll be there at graduation and get that degree.”

Because of the pandemic the graduation ceremony was postponed. Instead, Franklin received his diploma in the mail in June and attended commencement in August.

Franklin died just a year later on Sept. 9, 2021.

In 2008 the college opened the Harold A. Franklin Society to help support underrepresented male students. In 2015, officials unveiled a marker to commemorate Franklin’s achievements, stating that he simply left the university.

A new plaque was unveiled in 2021 at the recommendation of a task force .

“Dr. Franklin’s bold journey is the epitome of a spirit that is not afraid,” the plaque states. “His story continues to move our hearts, stimulate our minds and inspire our lives. The same spirit dwells within, reminding us that truth will always prevail.”

Auburn will host a commemoration of the 60th anniversary of Franklin’s enrollment at 4 p.m. on Tuesday, Jan. 9. A ceremony featuring several speakers will be held at the Mell Classroom Building and the Ralph Brown Draughon Library, where Franklin first registered for classes.

©2024 Advance Local Media LLC. Visit al.com. Distributed by Tribune Content Agency, LLC.

Scenes from Auburn University on Jan. 4, 1964, when Harold Franklin became the first black student to enroll.

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2024 baseball roster.

Seitter, Kevin

  • Position: Right-Handed Pitcher
  • Height: 6-1
  • Weight: 200
  • Class: Senior
  • Hometown: Ridgewood, N.J.
  • High School: Ridgewood HS
  • Prev School: Quinnipiac

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Usher got married on the day of his Super Bowl halftime performance. Meet his wife and 4 children.

  • Usher said his children gave him "notes" before his Super Bowl halftime performance on Sunday. 
  • Usher, 45, has three sons and one daughter. 
  • He began dating Jenn Goicoechea in 2019 and married her during the 2024 Super Bowl weekend. 

Insider Today

Usher and his longtime girlfriend, Jennifer Goicoechea, tied the knot on Sunday — the same day as his highly anticipated Super Bowl halftime performance. The couple obtained a marriage license on Thursday in Clark County, Nevada, multiple outlets reported, and had a ceremony in Las Vegas on Sunday.

The couple exchanged vows at an outdoor chapel known as Terrace Gazebo, and Jonetta Patton, Usher's mother, served as a witness, People said.

Usher shares two children, Sovereign Bo and Sire Castrello, with Goicoechea. He has two other children, Usher "Cinco" Raymond V and Naviyd Ely, with his ex-wife Tameka Foster.

Usher said his children had strong opinions about his Super Bowl LVIII halftime performance.

The "OMG" singer shared details about his family during a Thursday  interview with "The Talk."

"I've been receiving tons of notes from Naviyd," Usher said. He said his oldest son also gave him performance notes. "He gave me a few songs he felt like I should definitely cut, songs I should keep." 

Usher's children didn't appear with him on the Super Bowl stage, but the 45-year-old said they'd "be around." 

Over the years, Usher has spoken candidly about fatherhood and parenting, such as in 2020 when he  told People  that crying in front of his sons inspired his song "I Cry."

Usher's wife, Jennifer Goicoechea, is a senior vice president of A&R at Epic Records.

bio an 2021

Usher isn't the only person in his family who's heavily invested in music. Goicoechea, who grew up in Miami with her Italian mother and Puerto Rican father, told Rolling Out  in 2015 that she was interested in music from an early age and used to shadow her mother, who was a production manager for Act Productions, at work. 

Goicoechea said the experience she gained from working with her mother helped her eventually land a job with Ciara. She later founded her own management company, Boogs'N'Effect Management. She's now an SVP of A&R at Epic Records.

It's unclear when Goicoechea and Usher met, but there are photos of Goicoechea at Usher's birthday party in October 2018 . The two were later photographed kissing backstage at a 2019 concert at the Hollywood Bowl,  according to People.

Goicoechea has made several public appearances with Usher — including one at Vanity Fair's 2023 Oscar party — and became a fixture on his Instagram page. In October 2023, Usher celebrated her birthday with a sweet  Instagram post . 

Goicoechea and Usher have two children. Their daughter, Sovereign Bo,  was born in September 2020, while their son, Sire Castrello,  arrived in October 2021. 

Usher's eldest son, Usher "Cinco" Raymond V, was born in 2007.

bio an 2021

Usher and Foster welcomed Cinco, now 16, in November 2007.

"We are so happy and proud of our beautiful son. What a blessing!" Usher said in a statement at the time.

In a November 2022  interview with Tamron Hall , Usher said that his son prefers to go by his nickname, Cinco, to separate his identity from his dad's.

In 2013, Cinco almost drowned after his arm got stuck in a pool drain while trying to retrieve a toy,  E! News reported . The next year, Cinco was diagnosed with type 1 diabetes. Usher praised his son's bravery in an interview with People. 

"A child that every day has to prick himself and has to be cautious of what he eats and also to carry this disorder around; that really is the type of bravery that we all aspire to have," he said.

Usher's second son, Naviyd Ely, was born in 2008.

bio an 2021

Foster and Usher welcomed Naviyd in December 2008,  according to People . He's now 15.

"Tameka and the baby are doing fine," a representative said in a statement at the time. 

During his November 2022 interview with Tamron Hall, Usher said Naviyd had a love for entertainment and often watched his dad's shows. Usher added that Naviyd's isn't afraid to critique him. 

"He's like, 'You missed this thing. you didn't do this thing.' And I'm like, 'Yeah, that's the point. It's not supposed to be the same every night,'" Usher said. 

Following the release of "Hands of Stone," a 2016 sports film he starred in, Usher told People that he was going to take back from his career to focus on his children. 

Naviyd has made several public appearances with his father, including accompanying Usher to his Hollywood Walk of Fame ceremony in September 2016.

Usher's only daughter, Sovereign Bo, was born in 2020.

View this post on Instagram A post shared by Jennifer Goicoechea (@boogsneffect)

Usher announced his daughter's birth in a September 2020  Instagram post . She's now 3 years old.

"We are feeling blessed and full of love with the arrival of our beautiful baby girl, Sovereign Bo Raymond," he wrote in the caption. ""Isn't She Lovely" by Stevie Wonder on repeat."

Usher shared details about his daughter's name in a May 2021  interview with "Extra ."

"Sovereign, man, is such a beautiful word and name to me, you know, a supreme ruler is obviously the defined name," he said. "She's definitely ruling the household," he added, calling her his "my little 'reign-bo.'"

Sovereign appeared in a video for  Usher's single "Ruin" released on February 2.

Usher's youngest son, Sire Castrello, was born in October 2021.

View this post on Instagram A post shared by Usher (@usher)

Usher announced the birth of his son Sire Castrello, now 2, in an October 2021  Instagram post.  

"Hi my name is Sire Castrello Raymond … I am the newest addition to the Raymond crew. I was born Sept 29 2021 at 6:42pm weighing 7lbs 13oz. Hear me roar … A.K.A Ra Ra," he wrote in the caption.

On " The Ellen DeGeneres Show ," Usher said he did a "terrible job" choosing the music playlist during Sovereign's birth and tried to redeem himself during Sire's birth. 

"The second time, I came fully equipped. I had my Mophie. I had speakers. I had backup batteries," Usher said. "I had a whole playlist that I had worked on for about two weeks. It was crazy. It was great."

Usher has shared photos of Sire to his Instagram account, including pictures of his son's first birthday in September 2022. 

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GSK completes acquisition of Aiolos Bio for up to $1.4 bln

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US FDA to review Sarepta's Duchenne gene therapy for traditional approval

Sarepta Therapeutics said on Friday that the US FDA would review an application seeking traditional approval for its gene therapy to treat a muscle-wasting disorder by June 21, months after it failed the main goal of a confirmatory trial.

Cuban biologists unravel mysteries of bird migration

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